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GenomicsEffect of pharmacological inhibition of SMYD3 on gene expression in patient-derived CRC-SCs
Effect of pharmacological inhibition of SMYD3 on gene expression in patient-derived CRC-SCs
PRJNA1101506 | ENA
TranscriptomicsEffect of pharmacological inhibition of SMYD3 on gene expression in patient-derived CRC-SCs
Cancer stem cells (CSC) are responsible for colorectal cancer (CRC) chemoresistance, recurrence, and metastasis. Therefore, it has become crucial finding critical molecular stemness targets that are essential for tumor growth. Here, we performed an extensive in vitro and in vivo molecular and functi...
ORGANISM(S): Homo sapiens 
2025-06-17 | GSE264227 | GEO
ProteomicsTargeting Lysine-Specific Demethylase 1 (KDM1A/LSD1) Impairs Colorectal Cancer Tumorigenesis by Affecting Cancer Cells Stemness, Motility and Differentiation
Among all cancers, colorectal cancer (CRC) is the 3rd most common and the 2nd leading cause of death worldwide. New therapeutic strategies are required to target cancer stem cells (CSCs), a subset of tumor cells highly resistant to present-day therapy and responsible for tumor relapse. CSCs display ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037259 | Pride
Epigenome Kdm1a Tumor Proteome Crc-scs Lc-ms/ms 
TranscriptomicsMutual interaction between Schwann cells and CD4+T cells promotes the progression of perineural invasion in colorectal cancer [RNA-seq]
Background: Perineural invasion (PNI) is a common pathological feature associated with poor prognosis of colorectal cancer (CRC). However, the mechanisms underlying PNI formation and its relationship with CD4+T cells within the tumor immune microenvironment remain unclear. Aims: This study investiga...
ORGANISM(S): Homo sapiens 
2026-04-14 | GSE327488 | GEO
GenomicsMutual interaction between Schwann cells and CD4+T cells promotes the progression of perineural invasion in colorectal cancer [ATAC-seq]
Background: Perineural invasion (PNI) is a common pathological feature associated with poor prognosis of colorectal cancer (CRC). However, the mechanisms underlying PNI formation and its relationship with CD4+T cells within the tumor immune microenvironment remain unclear. Aims: This study investiga...
ORGANISM(S): Homo sapiens 
2026-06-30 | GSE327650 | GEO
TranscriptomicsTargeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility and differentiation
We explored the potential role of KDM1A targeting in CRC by characterizing the effect of KDM1A silencing in differentiated Colorectal Cancer Stem Cells human (CRC-SCs).
ORGANISM(S): Homo sapiens 
2023-06-27 | GSE216513 | GEO
TranscriptomicsEffect of stable genetic ablation and pharmacological inhibition of SMYD3 on gene expression in CRC cell line (HCT-116)
Cancer stem cells (CSC) are responsible for colorectal cancer (CRC) chemoresistance, recurrence, and metastasis. Therefore, it has become crucial finding critical molecular stemness targets that are essential for tumor growth. Here, we performed an extensive in vitro and in vivo molecular and functi...
ORGANISM(S): Homo sapiens 
2025-06-17 | GSE264157 | GEO
TranscriptomicsThe Oncogenic Role of Prostate Stem Cell Antigen (PSCA) in Colorectal Cancer: Implications for Targeted Therapy
Prostate stem cell antigen (PSCA), a pivotal member of the lymphocyte antigen-6 (Ly6) protein family, has been implicated in the tumorigenesis and neoplastic progression of diverse cancer types. In this study, we conducted a thorough investigation into the role of PSCA in the development of colorect...
ORGANISM(S): Homo sapiens 
2026-08-05 | GSE337374 | GEO
UnknownNFATC2 is a novel therapeutic target for colorectal cancer stem cells.
Not available
S-EPMC6199214 | biostudies-literature
ProteomicsMutual interaction between Schwann cells and CD4+T cells promotes the progression of perineural invasion in colorectal cancer
This study investigated the role of CD4+T cells in the development and progression of PNI in CRC by examining the interactions between Schwann cells (SCs), primary glial cells in peripheral nerves, and CD4+T cells.
ORGANISM(S): Homo Sapiens 
PXD077113 |
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