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ProteomicsFbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling
In Drosophila melanogaster, Fbxo42 acts downstream of Unfolded Protein Response activation but upstream of the apoptotic machinery. Fbxo42 associates through its N-terminal F-box domain with SkpA, a component of the RBX-SCF E3 ubiquitin ligase complex. Hence, in order to uncover Fbxo42 substrates, w...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-07-01 | PXD065621 | Pride
Alaxin-2 Upr Fbxo42 Xbp1 
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
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