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MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
MetabolomicsActivated ATF6α is a hepatic tumor driver restricting immunosurveillance

Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF...

2025-11-17 | MTBLS13241 | MetaboLights
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DAX]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44949 | biostudies-arrayexpress
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DYG]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44950 | biostudies-arrayexpress
TranscriptomicsThe eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves translational and transcriptional changes in gene expression aimed at expanding the ER processing capacity and alleviating cellular injury. Three ER ...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-29929 | biostudies-arrayexpress
ProteomicsPotential ATF6 regulatory proteins were screened by proteomics using pancreatic tissues of PRSS1 transgenic mice treated with caerulein
Humanized PRSS1 transgenic mice were constructed and treated with caerulein to mimic the development of human AP and CP. Potential ATF6 regulatory proteins in pancreatitis were screened by proteomics using pancreatic tissues of PRSS1 AP mice.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD016703 | Pride
Prss1 Atf6 Dia Mouse Pancreatitis 
GenomicsMultiexon deletion alleles of ATF6 linked to achromatopsia
Multiexon deletion alleles of ATF6 linked to achromatopsia
PRJNA644639 | ENA
GenomicsThe Unfolded Protein Response Regulator, ATF6, Promotes Mesodermal Differentiation
The Unfolded Protein Response Regulator, ATF6, Promotes Mesodermal Differentiation
PRJNA418171 | ENA
ProteomicsATF6 promotes colorectal cancer growth and stemness by regulating the Wnt pathway
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) homeostasis by sensing protein-folding stress and orchestrating cellular adaptation via the ER-transmembrane proteins IRE1, PERK and ATF6. Malignant cells can co-opt UPR signaling by IRE1 and PERK to sustain tumor growth; howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095581 | MassIVE
GenomicsMacrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription
Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription
PRJNA1031204 | ENA
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