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TranscriptomicsExpression data from PARK2 overexpression in U251 cells
PARK2 (PARKIN) is an E3 ubiquitin ligase whose dysfunction has been associated with the progression of Parkinsonism and human malignancies, and its role in cancer remains to be explored. In this study, we investigated its role in glioma. We used microarrays to detail the global programme of gene exp...
ORGANISM(S): Homo sapiens 
2014-10-03 | E-GEOD-61973 | biostudies-arrayexpress
TranscriptomicsKnockout PTTG1 HCT116 cells
To identify potential PTTG1-targeted genes, total RNA from PTTG1+/+ and PTTG1-/- HCT 116 cells was isolated using the RNeasy Kit (Qiagen) and analyzed using Illumina microarrays (HumanHT-12_V4). Raw data were processed according to the manufacturerâ??s standard procedure and further analyzed using ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-58863 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsThe genomic landscape of nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic distributions, is poorly understood at the genetic level and is in need of effective therapeutic approaches. Here we determined the mutational landscape of 128 cases with NPC using whole-exome and targeted deep sequencing, as ...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-63381 | biostudies-arrayexpress
UnknownShort-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer.
Not available
S-EPMC4359257 | biostudies-literature
UnknownLow Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer.
Not available
S-EPMC4988784 | biostudies-literature
TranscriptomicsGene expression profiles of dasatinib-resistant and dasatinib-sensitive pancreatic cancer cell lines
Gene profiles from three dasatinib-resistant and three dasatinib-sensitive pancreatic cancer cell lines were compared by microarray analysis. RNA from three dasatinib-resistant (MiaPaCa2, Panc1, SU8686) and three dasatinib-sensitive (Panc0504, Panc0403, Panc1005) pancreatic cancer cell lines were ex...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-59357 | biostudies-arrayexpress
TranscriptomicsSNP data of acute promyelocytic leukemia samples
Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50K and 250K SNP...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14016 | biostudies-arrayexpress
UnknownCARD10, a CEBPE target involved in granulocytic differentiation.
Not available
S-EPMC6068032 | biostudies-literature
TranscriptomicsGene expression data of interleukin-7-dependent and BCR-ABL1-transformed pre-B cells
This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including immunoglobulin light chain gene recombination were performed by withdrawal of interleuki...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21664 | biostudies-arrayexpress
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