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TranscriptomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression]
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
ORGANISM(S): Homo sapiens 
2012-08-06 | E-GEOD-38232 | biostudies-arrayexpress
TranscriptomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA)
In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutant Htt in d...
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38001 | biostudies-arrayexpress
GenomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq]
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
ORGANISM(S): Homo sapiens 
2012-08-07 | E-GEOD-38901 | biostudies-arrayexpress
GenomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (ChIP-Seq)
In HuntingtonM-bM-^@M-^Ys disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutan...
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-38000 | biostudies-arrayexpress
GenomicsTight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [ChIP-Seq]
A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through ...
ORGANISM(S): Homo sapiens 
2013-07-21 | E-GEOD-45852 | biostudies-arrayexpress
TranscriptomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1
This SuperSeries is composed of the following subset Series: GSE38000: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (ChIP-Seq) GSE38001: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA) Refer to individual Series
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38002 | biostudies-arrayexpress
TranscriptomicsThe reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy
Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Yet surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator Heat-Shock Factor 1 (HSF1) ...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-56252 | biostudies-arrayexpress
TranscriptomicsTight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [Gene Expression Data]
A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through ...
ORGANISM(S): Homo sapiens 
2013-07-21 | E-GEOD-45851 | biostudies-arrayexpress
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