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TranscriptomicsRNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryo
Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient. Most SCNT-generated embryos die after implantation because of unidentified, complex epigenetic errors in the process of postimplantation embryonic development. Here, we identified the most upstream level of dysfunction le...
ORGANISM(S): Mus musculus 
2011-11-17 | E-GEOD-33208 | biostudies-arrayexpress
TranscriptomicsImpeding Xist expression from the active X chromosome improves mouse somatic cell cloning
Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient because of aberrant genomic reprogramming. In addition to random reprogramming errors, we hypothesized the presence of specific errors as evidenced by common anomalies among clones. We found that Xist, which normally inact...
ORGANISM(S): Mus musculus 
2010-09-16 | E-GEOD-23181 | biostudies-arrayexpress
TranscriptomicsGenomic Reprogramming Errors Do Not Accumulate with Serial Recloning in the Mouse
To date, the success rate of serial animal cloning has decreased with increasing iterations and recloning has failed in all species after a few generations. This has suggested that recloning might be impossible because of the accumulation of lethal genetic or epigenetic abnormalities. Here, we carri...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-43476 | biostudies-arrayexpress
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