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TranscriptomicsConcerted action of Helios and Ikaros balances the strength of B cell receptor signaling and controls the expression of inositol 5-phosphatase SHIP
Inositol 5-phosphatase SHIP is differentially expressed in Ikaros and Helios deficient cells. In the absense of Ikaros SHIP is upregulated where as in the absense of Helios it is downregulated. Ikaros binds to the promoter of the SHIP gene. Article provides insight into the mechanisms of action Ikar...
ORGANISM(S): Gallus gallus 
2010-07-19 | E-GEOD-20946 | biostudies-arrayexpress
UnknownDevelopment of the Self Optimising Kohonen Index Network (SKiNET) for Raman Spectroscopy Based Detection of Anatomical Eye Tissue.
Not available
S-EPMC6658481 | biostudies-literature
TranscriptomicsTranscription profiling of chicken Pax5 deficient DT40 B cell line
PAx5 is indispensible for the committment if early lymphoid progenitors to the B cell lineage as well as for the development and maintenance of B cells. To better understand the functional importance of Pax5 in the later stages of B cell development and investigate the targets of Pax5 regulation, w...
ORGANISM(S): Gallus gallus 
2005-04-17 | E-MEXP-270 | biostudies-arrayexpress
TranscriptomicsExpression data from parental MDA-MB-231 cells and MDA-MB-231(SA) variant
Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, understanding of the underlying molecular mechanisms would be highly valuable. Here, we describe in vitro and in vivo evidence for the importance of serine biosynthesis in the metastasis of brea...
ORGANISM(S): Homo sapiens 
2010-04-19 | E-GEOD-20085 | biostudies-arrayexpress
TranscriptomicsThe effect of miRNA overexpression on gene expression profile of MCF-7 cells
To identify microRNAs impacting estrogen receptor ERα expression in breast cancer, we have screened ER-positive breast cancer cells with a library of pre-miRs, and systematically monitored the ERα expression by protein lysate microarrays. There was a significant enrichment of the in silico predict...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14847 | biostudies-arrayexpress
UnknownDevelopment and Validation of the Predictive Model for Esophageal Squamous Cell Carcinoma Differentiation Degree.
Not available
S-EPMC7645151 | biostudies-literature
TranscriptomicsSystems biology approaches reveal low-dose effects of nanoparticles
Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq, we found that cationic nanoparticles are capable of triggering down-regulation of cell cycle-related genes in primary human bronchial epithelial cells at doses that do ...
ORGANISM(S): Homo sapiens 
2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress
UnknownAllograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions: A Randomized Clinical Trial.
Not available
S-EPMC10752261 | biostudies-literature
UnknownExploring the structure-activity relationships of ABCC2 modulators using a screening approach.
Not available
S-EPMC4461526 | biostudies-literature
UnknownRespiratory tract virus infections in the elderly with pneumonia.
Not available
S-EPMC6469155 | biostudies-literature
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