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TranscriptomicsEpigenome analysis of HCC samples with paired adjacent tissue
Genome wide DNA methylation profiling of paired adjacent and hepatocellular samples and 8 non-diseased liver samples. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples included 12 paired adjacent and 12...
ORGANISM(S): Homo sapiens 
2013-09-27 | E-GEOD-44909 | biostudies-arrayexpress
TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-68091 | biostudies-arrayexpress
TranscriptomicsExpression Data from DMSO or SRPIN803 treated ARPE-19 cells
We used microarrays to evaluate the effect of SRPIN803 on gene expression in ARPE-19 cells. ARPE-19 cells were treated with SRPIN803 (10 uM) or the negative control (0.1% DMSO) for 4 hours for Total RNA isolation and hybridization on Microarray.
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-62947 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of paired biopsies and explanted liver from hepatitis C virus (HCV)-infected individuals
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54101 | biostudies-arrayexpress
TranscriptomicsExpression profiles of 186-gene signature in Italian hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54099 | biostudies-arrayexpress
TranscriptomicsExpression profiles of 186-gene signature in U.S. hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54100 | biostudies-arrayexpress
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