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UnknownIrreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.
Not available
S-EPMC7083616 | biostudies-literature
UnknownIdentification of novel small molecules that inhibit STAT3-dependent transcription and function.
Not available
S-EPMC5479526 | biostudies-literature
UnknownSTAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes.
Not available
S-EPMC6345781 | biostudies-literature
UnknownTargeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients.
Not available
S-EPMC7021816 | biostudies-literature
UnknownA drug screening assay on cancer cells chronically adapted to acidosis.
Not available
S-EPMC6156858 | biostudies-literature
UnknownPLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia.
Not available
S-EPMC10484999 | biostudies-literature
ProteomicsInvestigating the target and off-target landscape of PLK1 small molecule inhibitor volasertib
In this study we aimed to identify off-targets of polo-like kinase 1 (Plk1) small molecule inhibitor volasertib. Plk1 is an important cell cycle kinase and an attractive target for anticancer treatment. Volasertib is ATP-competitive small molecules that may also block the ATP-pocket of other protein...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD024040 | Pride
Volasertib Lc-ms Leukemia Plk1 
ProteomicsInvestigating the target and off-target landscape of PLK1 small molecule inhibitor volasertib
In this study we aimed to identify off-targets of polo-like kinase 1 (Plk1) small molecule inhibitor volasertib. Plk1 is an important cell cycle kinase and an attractive target for anticancer treatment. Volasertib is ATP-competitive small molecules that may also block the ATP-pocket of other protein...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD023757 | Pride
Drug Tpp Lc-ms Leukemia 
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