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Transcriptomics5-azacytidine treatment reorganizes genomic histone modification patterns
Methylation of DNA in combination with histone modifications establishes an epigenetic code that ensures the proper control of gene expression. Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a ...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-20598 | biostudies-arrayexpress
TranscriptomicsUsing ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells
We compared 12 different cell populations, including embryonic stem cells before and during differentiation into embryoid bodies as well as various types of normal and tumor cells to determine if pluripotent vs. differentiated cell types use different mechanisms to establish their transcriptome. We ...
ORGANISM(S): Mus musculus 
2008-03-31 | E-GEOD-10504 | biostudies-arrayexpress
TranscriptomicsZNF274 colocalizes with the histone methyltransferase SETDB1 at ZNF 3' ends.
Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are expressed in a given cell type. Thus, cell fate is mainly determined by cell type-specific silencing of transcription factors that drive different cellular lineages. Several hi...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-24480 | biostudies-arrayexpress
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