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TranscriptomicsTranscription profiling of human MCF-7 breast cancer cells treated with E2, ICI 182,789 (ICI), Raloxifene (Ral), and/or trans-hydroxytamoxifen (TOT)
MCF-7 breast cancer cells were treated with E2, ICI 182,789 (ICI), Raloxifene (Ral), and/or trans-hydroxytamoxifen (TOT) for 8 or 48 h. Duplicate samples are labeled set A or set B.
ORGANISM(S): Homo sapiens 
2007-09-27 | E-GEOD-848 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cancer cell line MCF-7 - estrogen effects where MCF7 is co-expressing ERa and ERb
Two subtypes of the estrogen receptor, ERalpha and ERbeta, mediate the actions of estrogens, and the majority of human breast tumors contain both ERalpha and ERbeta. To examine the possible interactions and modulatory effects of ERbeta on ERalpha activity, we have used adenoviral gene delivery to pr...
ORGANISM(S): Homo sapiens 
2009-04-24 | E-GEOD-4006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response to estradiol by human osteosarcoma cells expressing estrogen receptors alpha or beta
Estrogens exert many important effects in bone, a tissue that contains both estrogen receptors alpha and beta (ERalpha and ERbeta). To compare the actions of these receptors, we generated U2OS human osteosarcoma cells stably expressing ERalpha or ERbeta, at levels comparable to those in osteoblasts,...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1153 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF-7 breast cancer cell line transfected with adenovirus expressing Erbeta treated with estrogen or tamoxifen reveals tamoxifen can selectively regulate a unique set of >60 genes, which are minimally regulated by estradiol (E2) or raloxifene.
The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatory actions of estrogen, although tamoxifen can also have some estrogen-like agonist effects. Here, we rep...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4025 | biostudies-arrayexpress
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