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MetabolomicsIntra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type-2 diabetes
In this study we explored a unique cohort of 43 samples to build a map of metabolites varying in T2D across five different tissues (subcutaneous adipose tissue, liver, pancreatic islets, skeletal muscle and blood serum). The samples originate from the Excellence in Diabetes biobank (EXODIAB) in Swed...
2018-10-08 | MTBLS690 | MetaboLights
MetabolomicsIntegration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (...
2020-01-06 | MTBLS1051 | MetaboLights
TranscriptomicsPhenotypically concordant and discordant monozygotic twins display different DNA copy number variation profiles (SNP)
The exploration of copy number variation (CNV), notably of somatic cells, is an understudied aspect of genome biology. Any differences in the genetic make-up between twins derived from the same zygote represent an extreme example of somatic variation. We studied 19 pairs of monozygotic twins with ei...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9608 | biostudies-arrayexpress
UnknownTranslational repression contributes greater noise to gene expression than transcriptional repression.
Not available
S-EPMC2716471 | biostudies-literature
TranscriptomicsSomatic mosaicism for copy number variation in differentiated human tissues
Genetic variation is responsible for the generation of phenotypic diversity, including susceptibility to disease. Two major types of variation are known: single nucleotide polymorphisms (SNPs) and a more recently discovered structural variation, involving changes in copy number (CNVs) of kilobase- t...
ORGANISM(S): Homo sapiens 
2008-09-16 | E-GEOD-9598 | biostudies-arrayexpress
UnknownA strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements.
Not available
S-EPMC3371767 | biostudies-literature
UnknownRandomized Comparison of Two New Methods for Chest Compressions during CPR in Microgravity-A Manikin Study.
Not available
S-EPMC8836939 | biostudies-literature
UnknownEnhanced Protective Immunogenicity of Homodimeric Borrelia burgdorferi Outer Surface Protein C.
Not available
S-EPMC5216437 | biostudies-literature
UnknownCoexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration : Novel autoantibodies in GAD65 encephalitis
Not available
S-EPMC12297844 | biostudies-literature
UnknownProteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics.
Not available
S-EPMC5221611 | biostudies-literature
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