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UnknownMulti-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.
Serum lipid levels, which are influenced by both genetic and environmental factors, are key determinants of cardiometabolic health and are influenced by both genetic and environmental factors. Improving our understanding of their underlying biological mechanisms can have important public health and ...
S-EPMC12179276 | biostudies-literature
UnknownCorrection: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
[This corrects the article DOI: 10.1371/journal.pgen.1006528.].
S-EPMC5567921 | biostudies-literature
UnknownGenome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults...
S-EPMC5407576 | biostudies-literature
UnknownCommon variants associated with plasma triglycerides and risk for coronary artery disease.
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common va...
S-EPMC3904346 | biostudies-literature
UnknownDiscovery and refinement of loci associated with lipid levels.
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individual...
S-EPMC3838666 | biostudies-literature
UnknownRare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C l...
S-EPMC4889017 | biostudies-literature
UnknownGenome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% Europea...
S-EPMC5414044 | biostudies-literature
UnknownThe genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 ...
S-EPMC5042863 | biostudies-literature
UnknownGenetic studies of body mass index yield new insights for obesity biology.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individual...
S-EPMC4382211 | biostudies-literature
UnknownNew genetic loci link adipose and insulin biology to body fat distribution.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide asso...
S-EPMC4338562 | biostudies-literature
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