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ProteomicsHMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, which prevents Ku70-DNA interaction, in human AD postmor...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028089 | Pride
Hmgb1 Ku70 Phosphorylation Alzheimer's disease 
TranscriptomicsmiRNA gene expression profiles from osteosarcoma samples and cell lines
Although the introduction of combined neoadjuvant chemotherapy has significantly prolonged the survival, the outcome of OS patients with poor response to chemotherapy is still unfavorable. To develop new therapeutics the elucidation of the entire molecular pathway regulating OS cell proliferation is...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-30934 | biostudies-arrayexpress
ProteomicsLimited proteolysis for PTM analysis
PTMs on a mycobacterial DNA-binding protein with a long, lysine-rich, intrinsically disorders region were analyzed by limited proteolysis with trypsin, unveiling a massive methylation of most lysine residues of the protein in quantitative manner, which was lacked in the recombinant version of the pr...
ORGANISM(S): Escherichia Coli Mycobacterium Tuberculosis Mycolicibacterium Smegmatis Mc2 155 
2024-06-14 | PXD042969 | JPOST Repository
TranscriptomicsExpression profiling of prostate cell lines by miRNA array
Prostate cancer (PCa) is the most common malignant carcinoma that develops in men in Western countries. Up to 30% of patients continue to suffer from disease progression following radical prostatectomy. Therefore, better prognostic markers and molecular targets for cancer treatment are needed. Micro...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-40026 | biostudies-arrayexpress
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