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TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
TranscriptomicsIdentification of genes differentially expressed in lung cancer cells after the transfection of miR-221 or miR-222.
To evaluate involvement of miR-221 and miR-222 in lung cancer, we investigated the effects of miR-221 and miR-222 overexpression on six lung cancer cell lines as well as one immortalized normal human bronchial epithelial cell line. Two cell lines, H3255 and H1299 with no replicates were studied. Ce...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-57676 | biostudies-arrayexpress
UnknownStudy of microRNA associated with metformin?s anti-tumor effect [pancreatic cancer]
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-37406 | biostudies-other
TranscriptomicsGene expression profiles of epithelial cells infected with microRNA-negative and -positive Epstein-Barr viruses
The Epstein-Barr virus (EBV) encodes its own microRNAs (miRNAs); however, their biological roles remain elusive. The commonly used EBV B95-8 strain lacks a 12 kb genomic region, known as BamHI A Rightward Transcripts (BART) locus, which encodes a number of viral miRNAs (BART miRNAs). These miRNAs ar...
ORGANISM(S): Homo sapiens 
2015-02-05 | E-GEOD-58723 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of a genome-reduced strain in Schizosaccharomyces pombe
Gene number of the fission yeast Schizosaccharomyces pombe is the lowest in free-living eukaryotes. We further reduced the gene number to examine a minimal gene set required for growth. The genome-reduced strain, named ASP3894, has four chromosomal deletion regions: 168.4 kb deletion in the left arm...
ORGANISM(S): Schizosaccharomyces pombe 
2013-05-01 | E-GEOD-38620 | biostudies-arrayexpress
TranscriptomicsStudy of microRNA associated with metformin’s anti-tumor effect in cholangiocarcinoma
The miRNAs expression was markedly altered with the treatment of metformin in vivo and various miRNAs induced by metformin also may contribute to tumor growth of cholangiocarcinoma in vivo. Using a custom microarray platform, we analyzed the expression levels of 985 human miRNA probes in the tumorou...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-71905 | biostudies-arrayexpress
TranscriptomicsThe histone chaperone Spt6 is required for AID target determination through H3K4me3 regulation
H3K4me3 plays a critical role in the activation-induced cytidine deaminase (AID)-induced DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during class-switch recombination (CSR). The histone chaperone complex facilitates chromatin transcription (FACT) is responsible f...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-35334 | biostudies-arrayexpress
TranscriptomicsMicroRNA profile in hepatic epithelioid hemangioendothelioma
To elucidate the aetiology of HEH, especially with regard to microRNA (miRNA) profiles, samples obtained from three different parts of both normal and tumour tissues were analysed . The details of RNA extraction have been described in our previous reports. Interestingly, 16 miRNAs were significantly...
ORGANISM(S): Homo sapiens 
2016-03-15 | E-GEOD-66794 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of induced cardiomyocytes(iCMs)
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-56913 | biostudies-arrayexpress
TranscriptomicsSH-SY5Y cells: DMSO vs. clioquinol
Transcriptional profiling of human SH-SY5Y neuroblastoma cells comparing DMSO-treated control cells with those treated with 50 microM clioquinol (CQ) for 24 h. Two-condition experiment, DMSO vs. CQ . Biological replicates: 1DMSO, 1 CQ. One replicate per array.
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-32173 | biostudies-arrayexpress
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