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TranscriptomicsDevelopment of microRNA (miRNA) expression signatures for mouse glioma-initiating cells (GICs)
To identify a novel miRNA that is aberrantly expressed in GICs, we analyzed differences in miRNA expression between the mouse GICs, NSCL61 and OPCL61, showing characteristic features of cancer stem cell, and their parental cells by miRNA microarrays. neural stem cells, glioma-initiating cells (GICs)...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-61080 | biostudies-arrayexpress
TranscriptomicsExpression profiles of mouse glioma-initiating cells.
To identify factors involved in glioma-initiating cells (GICs), we compared gene expressions between GIC-like cells and non-GICs. p53-deficient Neural stem cells (NSCs), oligodendrocyte precursor cells (OPCs), and astrocytes (ASTs) were transfected with pCMS-EGFP-HRasL61 and pBabe-neo by electropora...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-28091 | biostudies-arrayexpress
TranscriptomicsExpression profiling of sox11-expressing glioma-initiating cell-like cells
To identify factors involved in tumorigenicity of glioma-initiating cells (GICs), we compared gene expression in GIC-like cells with and without sox11 expression. We established sox11-expressing mouse glioma-initiating cell (GIC)-like cell line (NSCL61s), NSCL61s-sox11, which lost tumorigenicity whe...
ORGANISM(S): Mus musculus 
2009-11-30 | E-GEOD-17076 | biostudies-arrayexpress
TranscriptomicsExpression profiles of mouse glioma-initiating cell-like subclones
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2009-12-01 | E-GEOD-17101 | biostudies-arrayexpress
TranscriptomicsExpression profiling of mouse glioma-initiating cell-like cells (GICs) and non-GICs
To identify factors involved in glioma-initiating cells (GICs), we compared gene expression between GIC-like cells and non-GICs. Neural stem cells (NSCs) were transfected with pCMS-EGFP-HRasL61 and pBabe-neo by electroporation and cultured in 0.5 mg/ml neomycin. The GFP-positive stable NSCs (NSCL61s...
ORGANISM(S): Mus musculus 
2009-11-30 | E-GEOD-17062 | biostudies-arrayexpress
TranscriptomicsExpression profile of Ceacam1 downstream genes in NSC and NSCL61
To identify Ceacam1 downstream factors, we compared gene expressions between NSCs and Ceacam1L-expressing NSC and between NSCL61 and Ceacam1shRNA-expressing NSCL61. We established Ceacam1L-expressing NSC and Ceacam1shRNA-expressing NSCL61s. We think that genes, which are differently expressed betwee...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-70023 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for miR-340 overexpressing human glioma-initiating cells (GICs)
To identify functional targets of miR-340, we compared the gene expression profiles of miR-340 overexpressing human GICs with the profiles of their parental cells. The precursor form of miR-340 or control miRNA was overexpressed in glioma cells using miRNA lentiviral particles. The cells were incuba...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-61078 | biostudies-arrayexpress
TranscriptomicsDevelopment of microRNA (miRNA) expression signatures for human glioma-initiating cells (GICs)
To identify a novel miRNA that is aberrantly expressed in GICs, we analyzed differences in miRNA expression between the human GICs and glioma cell lines and neural stem cells by miRNA microarrays. We examined the miRNA expression profiles of five human GICs that were obtained from human glioma sampl...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-61079 | biostudies-arrayexpress
TranscriptomicsTarget of Ascl1 in CG4 cell
To identify the downstream targets of transcription factor Ascl1, transcriptional profiling of rat glial cell line, CG4 cell, transfected with either Ascl1 or mock control was performed. Comparison was performed between Ascl1 overexpressing CG4 cell and mock control transduced cell on 3D-Gene rat mR...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-22157 | biostudies-arrayexpress
TranscriptomicsMetastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation
Specification to primordial germ cells (PGCs) occurs under the mesoderm induction signals during gastrulation. Here, we found that Akt activation in embryonic stem (ES) cells generated self-renewing spheres during mesodermal differentiation induction and that the differentiation status of the spher...
ORGANISM(S): Mus musculus 
2010-04-30 | E-GEOD-18813 | biostudies-arrayexpress
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