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ProteomicsProteomics of Human Hepatoma Huh-7 Cells Treated by Three Multi-RTK Inhibitors
Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for the patients with advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on the mechanism underlin...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034073 | Pride
Huh-7 cells Proteomics Multi-rtk inhibitors 
ProteomicsQuantitative proteomics characterization on the effect and mechanism of trichostatin A on hippocampus of type II diabetic mice
Cognitive dysfunction is the main feature of diabetic encephalopathy (DE). The effect and mechanism of trichostatin A (TSA) on cognitive function of diabetic mice is not elucidated. Our study revealed the key pathways and vital hubgenes of the effect of TSA on hippocampus of type II diabetic mice, i...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD036588 | Pride
Proteomics Diabetic encephalopathy Cognitive function Drug screening Trichostatin a 
ProteomicsA Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
A Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
ORGANISM(S): Mus Musculus 
2025-08-25 | PXD067684 |
ProteomicsIntegrated Peptidomic/Proteomic identification of novel cognition-enhancing peptides from Cerebroprotein Hydrolysate that protect against glutamate-induced excitotoxicity in PC12 cells
Cerebroprotein Hydrolysate (CH) is a nutrient extracted from porcine brain tissue that is rich in bioactive peptides. This study first demonstrated that CH exhibits significant learning and memory enhancement activity through behavioral experiments in APP/PS1 mice. However, the specific components a...
ORGANISM(S): Rattus Rattus Mus <genus> Pigmentiphaga Sp. D-2 
2025-09-14 | PXD068440 |
UnknownAnti-M1R/B6R antibody characterization and bispecific design for enhanced orthopoxvirus protection
Not available
S-SCDT-10_1038-S44321-025-00299-Z | biostudies-other
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