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ProteomicsMetabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in 2 nonalcoholic steatohepatitis
In this study Guo et al. revealed an endocrine pathway regulated by skeletal muscle IRF4 that manipulates liver pathology. Mice with skeletal muscle specific ablation of IRF4 show ameliorated liver steatosis, inflammation, and fibrosis, without changes in body weight on nonalcoholic steatohepatitis ...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-13 | PXD045324 | Pride
Mouse serum lcms 
ProteomicsLPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis
Among the diseases caused by Toll-like receptor 4 (TLR4) abnormal activation by bacterial endotoxin, sepsis is the most dangerous one. The reprogramming of macrophages plays a crucial role in orchestrating the pathogenesis of sepsis. However, the precise mechanism underlying TLR4 activation in macro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-01 | PXD052433 | Pride
Tlr4 Myd88 Sepsis 
ProteomicsProteomics and Organoid Culture Reveal the Underlying Pathogenesis of Hashimoto's Thyroiditis
To understand Hashimoto's Thyroiditis and translate this knowledge to clinical applications, we took mass spectrometric analysis on thyroid tissue fine-needle puncture from HT patients and healthy people in an attempt to make a further understanding of the pathogenesis of Hashimoto's Thyroiditis.
ORGANISM(S): Homo Sapiens 
2021-09-10 | PXD028448 |
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