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MetabolomicsC56BL6 WT or MyD88KO BMDM stimulated with different TLRs (part-IV)
Not available
ORGANISM(S): Mus musculus 
ST001344 | MetabolomicsWorkbench
TranscriptomicsReduced atherosclerosis in MyD88 null mice
This series represents a comparison of gene expression in mouse aorta from MyD88-/-, apoE-/- mice versus apoE-/- control mice fed a high fat diet for 8 weeks, causing atherosclerotic lesion development. 5 MyD88-/-, apoE-/- mice were compared to 5 apoE-/- control mice and dye swap replicated for a to...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-1058 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lungs from wild type and MyD88 knockout mice infected with Chlamydia pneumoniae to explore the influence of MyD88 on induction of immune responses.
Chlamydia pneumoniae, an obligate intracellular bacterium, causes pneumonia in humans and mice. Toll-like receptors and the key adaptor molecule MyD88 play a critical role in inducing immunity against this microorganism and are crucial to survive the infection. To explore the influence of MyD88 on i...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6688 | biostudies-arrayexpress
TranscriptomicsHighly Recurrent MYD88 Mutations That Promote Human Lymphoma Cell Survival
The ABC subtype of diffuse large B cell lymphoma (DLBCL) remains the least curable form of this lymphoma despite recent advances in therapy. We have combined structural and functional genomics to triangulate on new oncogenic mechanisms and devise new therapeutic strategies. RNA interference screen r...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-22900 | biostudies-arrayexpress
TranscriptomicsAger (Rage) and Myd88 deletion in resected mouse livers
The effect of resection of mouse livers on survival serve as a model for the effect of resection of human livers, which are performed for both the purposes of removing sick tissue and for transplanting healthy tissue. When less than 70% of a mouse liver is resected, the mouse usually lives. However,...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-22873 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of intestinal tissue samples from germ-free and conventionally raised mice which are either wild-type or Myd88-/-
Whole-transcriptome survey of gene expression differences between germ-free (GF) and conventionally raised (CONV-R) mice. To assess the role of toll-like receptor signalling, both wild-type and Myd88 -/- mice were used. Four different tissues were harvested from 20 mice (5 WT CONV-R, 5 Myd88 -/- CON...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-17438 | biostudies-arrayexpress
TranscriptomicsMyD88-mediated signaling prevents development of adenocarcinomas of the colon via interleukin-18
Inflammation has pleiotropic effects on carcinogenesis and tumor progression. Signaling through the adaptor protein MyD88 promotes carcinogenesis in several chemically induced cancer models. Interestingly, we observed a protective role for MyD88 in the development of AOM/DSS colitis-associated cance...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-19793 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse pancreatic pericytes from MyD88-deficient and control mice
To define pericytic MyD88-dependent expression of cytokines and other immune mediators, pancreatic pericytes were isolated based on their YFP-labeling from Nkx3.2-Cre;EYFP and Nkx3.2-Cre;EYFP;MyD88 flox/flox transgenic mice.
ORGANISM(S): Mus musculus 
2023-12-31 | E-MTAB-13639 | biostudies-arrayexpress
TranscriptomicsMycobacterial TDM induces MyD88-dependent macrophage gene regulation
Determine the role of MyD88 during stimulation of macrophages with trehalose dimycolate (TDM)-coated beads by comparison of murine macrophage from wild-type and MyD88 knockout mice.
ORGANISM(S): Mus musculus 
2013-02-20 | E-MEXP-3815 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of mouse pancreatic islets from non-transgenic and pericyte MyD88-mutated mice
To elucidate the role of pericytic cytokines in islet inflammation, we interfered with the expression of MyD88, a key modulator of the IL1R1/TLR pathway, in pericytes using transgenic mice (Nkx3.2-Cre;MyD88 flox/flox) . To determine the impact on islet immune cells, we isolated CD45+ cells from the ...
ORGANISM(S): Mus musculus 
2023-12-31 | E-MTAB-13640 | biostudies-arrayexpress
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