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ProteomicsGlobal proteome of Atg5flox:CAG-CreTmx WT and KO neurons
The experiment was performed to identify autophagy targets in wildtype and autophagy-deficient primary neurons. Therefore, cortico-hippocampal neurons were isolated from Atg5flox:CAG-CreTmx mice and treated with Tamoxifen (Tmx) to induce the knockout (KO) or EtOH for wildtype (WT) in-vitro. WT and K...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD031487 | Pride
Atg5 ko Neurons Autophagy 
ProteomicsGlobal proteome of Atg5flox:Slc32a1-Cre:tdTomato FACS sorted WT and KO neurons
The experiment was performed to identify autophagy targets in wildtype and autophagy-deficient forebrain inhibitory neurons. Therefore, neurons were isolated from the cortex, hippocampus and striatum of 2-3 weeks old Atg5flox/flox:Slc32a1-Cretg/wt:tdTomato+ (KO) and Atg5wt/wt:Slc332a1-Cretg/wt:tdTom...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD031535 | Pride
Atg5 ko In-vivo proteome Neurons Autophagy 
ProteomicsGlobal proteome of Atg5flox:CamKIIα-Cre:tdTomato FACS sorted WT and KO neurons
The experiment was performed to identify autophagy targets in wildtype and autophagy-deficient forebrain excitatory neurons. Therefore, neurons were isolated from the cortex, hippocampus and striatum of 2-3 weeks old Atg5flox/flox:CamKIIα-Cretg/wt:tdTomato+ (KO) and Atg5wt/wt:CamKIIα-Cretg/wt:tdToma...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD031552 | Pride
Atg5 ko In-vivo proteome Neurons Autophagy 
UnknownNeurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological.
Not available
S-EPMC6396726 | biostudies-literature
ProteomicsLiver phosphoproteomics in response to AgRP activated neurons in the presence/absence of NPY
Autophagy represents a key regulator of aging and metabolism upon cell autonomous sensing of energy deprivation. We find that fasting in mice activates autophagy in liver paralleled by activation of hypothalamic AgRP neurons. Optogenetic and chemogenetic activation of AgRP neurons induces autophagy,...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-18 | PXD029247 | Pride
Phosphoproteomics Dia Liver Lc-ms/ms 
ProteomicsProximity proteomics on RPE1 stable cell lines with miniTurbo-p62 and ATG5 Knock-down to investigate p62 filaments and calcium-rich p62-enwrapped lipid droplets
The selective autophagy receptor p62/SQSTM1 (from hereon p62) is known to form higher-order filaments in vitro and to undergo liquid-liquid phase separation when mixed with poly-ubiquitin. We determined the full-length cryo-EM structure of p62 and elucidated a structured double helical filament scaf...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066163 | Pride
Human Lc-ms Biotinylation Miniturbo Atg5 kd 
UnknownInterleukin 6 and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Chronic Coronary Syndrome.
Not available
S-EPMC8387946 | biostudies-literature
UnknownLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
Not available
S-EPMC4985288 | biostudies-literature
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