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TranscriptomicsRNA-seq of small intestinal macrophages, neutrophils, CD103-CD11b+cDC and cryptopatch and ILF associated mononuclear phagocytes (CIA-MPh)
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. CIA-MPh expressed v...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9505 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of small intestinal dendritic cells from C57BL/6, RORgt-/- and RORgt-Cre x Ltb-flox mice
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. We could demonstrat...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9522 | biostudies-arrayexpress
GenomicsSimilarity and diversity of the tumor microenvironment in multiple metastases: critical implications for overall and progression-free survival of high-grade serous ovarian cancer.
The tumor microenvironment is pivotal in influencing cancer progression and metastasis. Different cells co-exist with high spatial diversity within a patient, yet their combinatorial effects are poorly understood. We investigate the similarity of the tumor microenvironment of 192 local metastatic le...
EGAS00001002065 | EGA
TranscriptomicsRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
To investigate the influence of Interleukin-22 (IL-22) on colonic intestinal stem cells, we assessed gene expression in these cells during homeostasis and after induction of DNA damage. IL-22 is a lymphocyte-derived cytokine that targets exclusively non-hematopoietic cells. The receptor is expressed...
ORGANISM(S): Mus musculus 
2019-01-01 | E-MTAB-6723 | biostudies-arrayexpress
GenomicsOvCan2
Digital images of ovarian cancer metastases
EGAD00010001099 | EGA
GenomicsYuanlab
Data Access Committee EGAC00001000433
EGAC00001000433 | EGA
TranscriptomicsGene profiling of HSCs in C57BL/6 TEL-SYK BM versus control
The aim of the study was to analyse gene expression differences in LT and ST HSCs in BM of TEL-SYK transplanted versus control C57BL/6mice
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2240 | biostudies-arrayexpress
TranscriptomicsFrequent occurrence of deletions in primary mediastinal B-cell lymphoma
Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of diffuse large B-cell lymphoma. PMBCL has been previously studied with a variety of genomic techniques resulting in frequent detection of chromosomal gains; however, chromosomal losses have been rarely reported. This finding contr...
ORGANISM(S): Homo sapiens 
2007-08-15 | E-GEOD-7383 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Burkitts lymphomas
The distinction between the Burkitt lymphoma and diffuse large B-cell lymphoma is imprecise using current diagnostic criteria. We applied transcriptional and genomic profiling to molecularly define Burkitt lymphoma. Gene expression profiling employing Affymetrix GeneChips (U133A) was performed in 22...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4475 | biostudies-arrayexpress
TranscriptomicsBCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer
Canonical Wnt signaling output is mediated by β-catenin, which interacts with LEF/TCF transcription factors and recruits a general transcriptional activation complex to its C-terminus. Its N-terminus binds BCL9/9L proteins, which bind co-activators that in mammals contribute to fine-tuning the tran...
ORGANISM(S): Mus musculus 
2015-11-08 | E-GEOD-60837 | biostudies-arrayexpress
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