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ProteomicsMapping the peptide binding groove of MHC class I
An essential element of adaptive immunity is the selective binding of peptide antigens by major histocompatibility complex (MHC) class I proteins and their presentation to cytotoxic T lymphocytes on the cell surface. Using native mass spectrometry, we here analyze the binding of peptides to an empty...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD027725 | Pride
Peptide-binding Hla-a Native ms Human Mhc class i 
ProteomicsDissociation of β2m from MHC Class I triggers formation of noncovalent, transient heavy chain dimers
At the plasma membrane of mammalian cells, major histocompatibility complex class I molecules (MHC-I) present antigenic peptides to cytotoxic T cells. Following the loss of the peptide and the light chain beta-2 microglobulin (beta2m), the resulting free heavy chains (FHCs) can associate into homoty...
ORGANISM(S): Homo sapiens (Human) 
2022-05-11 | PXD033485 | Pride
Hla-a Dimerization Native ms Human Mhc class i 
ProteomicsNative mass spectrometry of peptide-free and partially loaded MHC class I molecules
A disulfide-stabilized MHC class I molecule (HLA-A*02:01(Y84C/A139C), short dsA2) was characterized by native mass spectrometry. dsA2 was shown to be structurally intact in absence of any peptide whereas its wild type form was not. Furthermore, it was observed that the mutation did not disrupt the b...
ORGANISM(S): Homo sapiens (Human) 
2022-05-11 | PXD016708 | Pride
Peptide-binding Hla-a Native ms Human Mhc class i 
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