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UnknownHematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils.
Not available
S-EPMC3991581 | biostudies-literature
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
TranscriptomicsMYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress
TranscriptomicsGRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3
Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here we aimed ...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-47407 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-HIPO-01-12-2017-13:02:22:609-63 - samples
This dataset contains paired fastq files for LMS tumor samples
EGAD00001003828 | EGA
Genomicsena-DATASET-DKFZ-HIPO-01-12-2017-13:14:23:391-67 - samples
The data set contains paired end fastq files for whole exome sequencing data for Leiomyosarcoma tumor and control samples
EGAD00001003829 | EGA
Genomicsena-DATASET-DKFZ-HIPO-01-12-2017-12:36:36:554-60 - samples
The data set contains bam files aligned using bwa-0.7.8 mem -t 8 -R.
EGAD00001003827 | EGA
GenomicsIntegrative genomic and transcriptomic analysis of adult leiomyosarcoma (HIPO-028, HIPO-018, HIPO-021)
Leiomyosarcoma (LMS) is an aggressive mesenchmyal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically actionable genetic vulnerabilities, are largely unknown. We performed genomic and transcriptomic profiling of a large cohort of LMS tumors and id...
EGAS00001002437 | EGA
GenomicsDKFZ-HIPO Data Access Committee of Heidelberg Center for Personalized Oncology
Data Access Committee EGAC00001000452
EGAC00001000452 | EGA
TranscriptomicsTranscriptional profiling by array of pancreatic ductal adenocarcinoma xenograft models
We generated novel patient derived xenograft (PDX) and cell line -derived xenograft models for pancreatic ductal adenocarcinoma (PDAC) which reflect different molecular subtypes. Pancreatic ductal adenocarcinoma is currently the tumor with the fourth highest mortality rate. Recently, subtypes of PDA...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-MTAB-4029 | biostudies-arrayexpress
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