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TranscriptomicsHuman variation in PolII and NF-KappaB binding (RNA-seq study uninduced by TNF-alpha)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19466 | biostudies-arrayexpress
TranscriptomicsHuman variation in PolII and NF-KappaB binding (RNA-seq study with TNF-alpha induced)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19481 | biostudies-arrayexpress
GenomicsHuman variation in PolII and NF-KappaB binding (ChIP-seq study with NF-KappaB)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19485 | biostudies-arrayexpress
GenomicsHuman variation in PolII and NF-KappaB binding (ChIP-seq study with Pol II)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Pan troglodytes 
2010-03-22 | E-GEOD-19484 | biostudies-arrayexpress
UnknownImmortalization capacity of HPV types is inversely related to chromosomal instability.
Not available
S-EPMC5122336 | biostudies-literature
UnknownPrimate genome architecture influences structural variation mechanisms and functional consequences.
Not available
S-EPMC3785719 | biostudies-literature
ProteomicsKansl2 dependent acetylome study in primary Kansl2 (fl/fl) murine embryonic fibroblasts
As one of the most important post-translational protein modifications, lysine acetylation is catalyzed by lysine acetyltransferases (KATs), which catalyze the covalent attachment of an acetyl group to the N epsilon–residue of lysine. The histone acetyltransferase MOF, which represents the main histo...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-05 | PXD038521 | Pride
Kat8 regulatory nsl complex subunit 2  mef (murine embryonic fibroblast)  primary inducible kansl2 knock-out  cre-ert2  anti acetyl-lysine antibody  ptm enrichment 
ProteomicsLamin A acetylation shapes nuclear architecture and safeguards genomic integrity
The nuclear lamina constitutes more than a structural scaffold for the nucleus and plays a crucial role in protection of genomic integrity. Here we report that the loss of the lysine acetyl-transferase (KAT) MOF leads to nuclear architecture defects during interphase including micronuclei formation....
ORGANISM(S): Mus musculus (Mouse) 
2019-08-16 | PXD008539 | Pride
Acetylation Mouse Qexactive Lc-msms 
TranscriptomicsImmortalization capacity of HPV types is inversely related to chromosomal instability in immortal descendants.
Human papillomavirus (HPV) induced immortalization of human foreskin keratinocytes (HFK) is a two-step process, including 1) the bypass of replicative senescence and acquisition of an extended lifespan, and 2) the outgrowth of immortal cells. Our previous study showed that the immortalization capaci...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-72063 | biostudies-arrayexpress
TranscriptomicsIntrinsic glioma subtypes in EORTC 26951 (part 6)
Background: Intrinsic glioma subtypes (IGS) are molecularly similar tumors that can be identified based on unsupervised gene-expression analysis. Here, we have evaluated the clinical relevance of these subtypes within EORTC26951, a randomized phase III clinical trial investigating adjuvant procarbaz...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43353 | biostudies-arrayexpress
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