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ModelsCaruso2020 - Activation of the alternative complement pathway and effects on hemolysis
This model is based on the publication: Caruso A, Vollmer J, Machacek M, Kortvely E. "Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease." PLoS Comput Biol. 2020 Oct 2;16(10):e1008139. doi: 10.1371/journal.pcbi.1008139 Curation Comment: ...
2021-09-11 | MODEL2109110001 | BioModels
ProteomicsTFMI-3 plasma pull-down - MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked
MASP-3 is the third protease of the lectin pathway of the complement system, but its biological function has remained obscure. To elucidate its role in complement activation, we developed a specific MASP-3 inhibitor (named TFMI-3). In this work we unambiguously demonstrate that MASP-3 acts as the ex...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD003666 | Pride
Factor d Complement Alternative pathway Inhibitor Masp-3 Blood Directed protein evolution Lectin pathway 
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