Sort   by:  
 Page size 
TranscriptomicsmRNA expression data of 62 human medulloblastoma tumors
To identify molecular subtypes of medulloblastoma we have profiled a series of 62 medulloblastoma tumors. Unsupervised hierarchical cluster analysis of these data identified 5 distinct molecular subtypes. Manuscript submitted. Title: Identification of medulloblastoma subtypes with distinct genetic p...
ORGANISM(S): Homo sapiens 
2008-09-02 | E-GEOD-10327 | biostudies-arrayexpress
UnknownmRNA expression data of 62 human medulloblastoma tumors
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-10327 | biostudies-other
TranscriptomicsInactivation of CDK2 is synthetic lethal to MYCN-overexpressing cancer cells
Two genes have a synthetic lethal relationship when silencing or inhibition of one gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells wit...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-16480 | biostudies-arrayexpress
TranscriptomicsNOTCH3 is a master-regulator of motility in neuroblastoma and is essential for cell survival
Migratory embryonal neuroblasts give rise to several tissues, including the sympathetic nervous system (SNS). Neuroblastomas are paediatric tumours of the peripheral SNS with a highly variable prognosis. We observed that high NOTCH3 expression in neuroblastomas correlated with a poor prognosis. Expr...
ORGANISM(S): Homo sapiens 
2013-08-06 | E-GEOD-16477 | biostudies-arrayexpress
TranscriptomicsFOXO3a Is A Major Target Of Inactivation By PI3K/AKT Signaling In Aggressive Neuroblastoma
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the PI3K/AKT pathway in neuroblastoma is correlated with poor patient prognosis, but the precise downstream effectors mediating this effect have not been determined. Here, ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42762 | biostudies-arrayexpress
TranscriptomicsOTX2 drives medulloblastoma proliferation via direct regulation of cell cycle genes and inhibits differentiation
The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. The role of OTX2 in medulloblastoma and its downstream targets are uncle...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22875 | biostudies-arrayexpress
TranscriptomicsIntegrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma: MSX1
mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic pla...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-16481 | biostudies-arrayexpress
TranscriptomicsIntegrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma: MYCN
mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic pla...
ORGANISM(S): Homo sapiens 
2015-10-20 | E-GEOD-16478 | biostudies-arrayexpress
TranscriptomicsCOMPARATIVE TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS OF LGR5+ve STEM CELLS AND THEIR DAUGHTERS (AFFYMETRIX ARRAYS)
The identification of Lgr5 as an intestinal stem cell marker has made it possible to isolate and study primary intestinal stem cells. Applying quantitative mass spectrometry as well as transcriptomic analysis, we profiled the protein and gene changes between FACS-sorted Lgr5+ve stem cells and their ...
ORGANISM(S): Mus musculus 
2012-08-12 | E-GEOD-33948 | biostudies-arrayexpress
MetabolomicsCirculatory metabolomics reveals the association of the metabolites with clinical features in the patients with intrahepatic cholestasis of pregnancy

OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse pregnancy outcomes to the mother and fetus. As yet, the metabolic profiles and the association of the clinical features remain obscure.

METHODS: Fifty sev...

2022-03-01 | MTBLS2627 | MetaboLights
Sort   by:  
 Page size