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ProteomicsElevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism
Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. We use multiplex proteomics profiling to screen plasma fr...
ORGANISM(S): Homo sapiens (Human) 
2023-03-25 | PXD040913 | Pride
Human Blood plasma Venous thromboelism Complement factor 
ProteomicsPan-cancer plasma proteome profiling using SIS recombinant protein fragments reveals downregulation of proteins interacting with immunoglobulins in multiple myeloma
Mass spectrometry based on Data Independent Acquisition (DIA) strategies has developed into powerful tools suitable for precision medicine applications. Assays performed in this setting provide confident protein identification and precise quantification on an absolute scale when combined with stable...
ORGANISM(S): Homo Sapiens 
PXD037946 | panorama
ProteomicsBrain Creatine Kinase as a biomarker for Alzheimer’s disease
The creatine-phosphocreatine cycle serves as a crucial temporary energy buffering system in the brain, regulated by brain creatine kinase (CKB). CKB, responsible for reversible phosphorylation of creatine, plays a pivotal role in maintaining ATP levels. Alzheimer's disease (AD) has been linked to in...
ORGANISM(S): Homo Sapiens 
PXD050060 | panorama
ProteomicsMonitoring Biomarker Study in Becker Muscular Dystrophy using Data Independent Acquisition LC-MS/MS
Becker muscular dystrophy (BMD) is a rare and heterogenous form of dystrophinopathy caused by reduced expression of altered dystrophin protein. Gene therapies and exon-skipping therapies for the more severe form of dystrophinopathy, Duchenne muscular dystrophy (DMD), assume that disease progression ...
ORGANISM(S): Homo Sapiens 
2025-10-31 | PXD054253 | panorama
UnknownElevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Not available
S-EPMC10247781 | biostudies-literature
ProteomicsAddressing the Protease Bias in Quantitative Proteomics
Protein quantification strategies using multiple proteases have been shown to deliver poor inter-protease accuracy in label-free mass spectrometry experiments. By utilizing six different proteases with different cleavage sites, this study explores the protease bias and its effect on accuracy and pre...
ORGANISM(S): Homo Sapiens 
PXD033574 | panorama
ProteomicsLongitudinal Protein Profiling using Targeted Proteomics and Recombinant Standards
Spike-in of standards of known concentrations used in proteomics-based workflows is an attractive approach for both accurate and precise multiplexed protein quantification. Here, a quantitative method based on targeted proteomics analysis of plasma proteins using isotope-labelled recombinant standar...
ORGANISM(S): Homo Sapiens 
2021-03-15 | PXD020797 | panorama
ProteomicsAssessing the role of trypsin in quantitative plasma- and single-cell proteomics towards clinical application
Mass spectrometry-based bottom-up proteomics is rapidly evolving and routinely applied in large biomedical studies. Proteases are a central component of every bottom-up proteomics experiment, digesting proteins into peptides. Trypsin has been the most widely applied protease in proteomics, due to it...
ORGANISM(S): Homo Sapiens 
PXD042450 | panorama
ProteomicsTargeted Proteomics Using Stable Isotope Labeled Protein Fragments Enables Precise and Robust Determination of Total Apolipoprotein(a) in Human Plasma
Lipoprotein(a), also known as Lp(a), is an LDL-like particle composed of apolipoprotein(a) (apo(a)) bound covalently to apolipoprotein B100. Plasma concentrations of Lp(a) are highly heritable and vary widely between individuals. Elevated plasma concentration of Lp(a) is considered as an independent...
ORGANISM(S): Homo Sapiens 
2023-02-17 | PXD026976 | panorama
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