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GenomicsHigh-throughput semi-quantitative analysis of insertional mutations in heterogeneous tumors
Exploiting the full potential of insertional mutagenesis screens with retroviruses and transposons requires methods for distinguishing clonal from subclonal insertion events within heterogeneous tumor cell populations. Current protocols, based on ligation mediated PCR, depend on endonuclease based f...
ORGANISM(S): Mus musculus 
2011-08-11 | E-GEOD-22657 | biostudies-arrayexpress
TranscriptomicsAnalysis of copy number changes primary and metastatic colorectal cancer samples
Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently described to occur in a small percentage of tumors. The significan...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32711 | biostudies-arrayexpress
TranscriptomicsThe genomic and transcriptomic dynamics of treatment-naïve epithelial ovarian cancer
We reveal three-dimensional patterns of tumour growth by exploiting the unique metastasizing patterns of treatment naïve stage IIIC/IV epithelial ovarian cancer. We performed topographic mapping of structural genomic rearrangements, coding mutations, copy number changes and RNA expression in biopsi...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-47633 | biostudies-arrayexpress
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