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MetabolomicsHigh-resolution extracted ion chromatography, a new tool for metabolomics and lipidomics using a second-generation orbitrap mass spectrometer
Most analytical methods in metabolomics are based on one of two strategies. The first strategy is aimed at specifically analysing a limited number of known metabolites or compound classes. Alternatively, an unbiased approach can be used for profiling as many features as possible in a given metabolom...
2012-02-14 | MTBLS4 | MetaboLights
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
ProteomicsZFP57 is a regulator of postnatal growth and life-long health
Early-life factors, including nutrition, shape long-term health outcomes. Despite the essential role of lactation in maternal nutritional support, the influence of epigenetic factors on lactation and postnatal growth remains poorly understood. Zinc-finger protein 57 (ZFP57), is an epigenetic regulat...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-11-03 | MSV000099723 | MassIVE
UnknownA pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies
Not available
ORGANISM(S): Mus musculus (mouse) 
S-BSST651 | bioimages
ProteomicsFerroptotic Cell Death upon BCL2 Inhibition
B-cell acute lymphoblastic leukemia (B-ALL) is a leading cause of death in childhood and outcomes in adults remain dismal. There is therefore an urgent clinical need for therapies that target the highest risk cases. Mutations in the histone acetyltransferase CREBBP confer high-risk and increased che...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-04-01 | MSV000097461 | MassIVE
ProteomicsDefective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis
Atherosclerotic lesions show significant mitochondrial dysfunction but the underlying mechanisms and consequences remain unknown. Cardiolipin is a phospholipid found exclusively in the mitochondrial inner membrane, the site of oxidative phosphorylation. Tafazzin is a trans-acylase that acylates imma...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000099336 | MassIVE
ProteomicsIRP1 deficiency alters mitochondrial metabolism
Iron regulatory protein 1 (IRP1) is a post-transcriptional regulator of cellular iron metabolism. In mice, loss of IRP1 causes polycythemia through translational de-repression of hypoxia-inducible factor 2 (HIF2) mRNA, which increases renal erythropoietin production. Here we show that Irp1-/- mice d...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2026-01-13 | MSV000100449 | MassIVE
MetabolomicsmassPix: An R package for annotation and interpretation of mass spectrometry imaging data for lipidomics
Mass spectrometry imaging (MSI) experiments result in complex multi-dimensional datasets, which require specialist data analysis tools. Here we have developed massPix - an R package for analysing and interpreting data from MSI of lipids in tissue. MassPix is an open-source tool for the analysis and ...
2017-08-31 | MTBLS487 | MetaboLights
MetabolomicsMechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes (Mouse data)
Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols (TAGs) with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association s...
2017-03-02 | MTBLS327 | MetaboLights
MetabolomicsMechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes (Human data)
Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols (TAGs) with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association s...
2015-10-05 | MTBLS162 | MetaboLights
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