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TranscriptomicsDistinct transcriptional outputs associated with mono- and di-methylated histone H3 arginine 2
Dimethylation of histone H3 arginine 2 (H3R2me2) maintains transcriptional silencing by inhibiting Set-1 mediated trimethylation of H3K4. Here we demonstrate that arginine 2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (a) H3R2me1 does ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-06 | E-GEOD-14453 | biostudies-arrayexpress
TranscriptomicsOfd2+/-hypoxia
Investigation of mRNA expression level changes in S. pombeOfd2 (SPAP8A3.02c) deletion strain compared to wild-type strain at both normal oxygen (normoxia) and low oxygen (hypoxia) growth conditions. Four samples in total consisting of two S. pombeyeast strains, wild type (WT) and a gene deleted stra...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2011-08-05 | E-GEOD-31236 | biostudies-arrayexpress
TranscriptomicsRIP-seq to identify transcripts interacting with pluripotency factors in mouse embryonic stem cells
Sox2 is a master transcriptional regulator of embryonic development. Having found that Sox2 interacts with RNA-binding proteins, we designed an experiment to discover RNAs associated with Sox2 and other pluripotency factors. Briefly, we used RNA immunoprecipitation followed by high-throughput sequen...
ORGANISM(S): Mus musculus 
2019-02-11 | E-MTAB-7640 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 7SK knockdown in mouse embryonic stem cells
Transcriptome profiling of mouse embryonic stem cells following antisense knockdown of the non-coding RNA 7SK.
ORGANISM(S): Mus musculus 
2013-09-09 | E-MTAB-1585 | biostudies-arrayexpress
TranscriptomicsGenome-wide studies of histone Me2 SWIRM and polyamine oxidase domain homologues of mammalian LSD1
In order to gain a more global view of the activity of histone demethylases we report here studies of the two fission yeast SWIRM and polyamine oxidase domain homologues of mammalian LSD1. Consistent with previous work (Nicolas et al., 2006) we find that the two S. pombe proteins, which we name Swm...
ORGANISM(S): Schizosaccharomyces pombe 
2010-05-27 | E-GEOD-6224 | biostudies-arrayexpress
TranscriptomicsGriffiths JAK ESC
Transcriptional profiling comparison of mouse embryonic stem cells versus their JAK mutated counterparts, cultured both in the presence and absence of LIF (leukemia inhibitory factor).
ORGANISM(S): Mus musculus 
2011-04-18 | E-MTAB-416 | biostudies-arrayexpress
GenomicsMETABRIC
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary brea...
EGAS00000000083 | EGA
TranscriptomicsTranscriptional profiling of PADI4 overexpression and inhibition in mouse embryonic stem cells
The enzymatic activity of PADI4 was investigated by overexpression and chemical inhibition to determine the effects of arginine citrullination on histone displacement, reprogramming efficiency and the maintenance of pluripotent stem cells.
ORGANISM(S): Mus musculus 
2013-11-22 | E-MTAB-1975 | biostudies-arrayexpress
GenomicsHMM Segmented CNA (discovery set) - samples
Segmented (HMM) copy number aberrations (CNA); discovery set
EGAD00010000217 | EGA
GenomicsCBS Segmented CNV (discovery set) - samples
Segmented (CBS) copy number variants (CNV); discovery set
EGAD00010000214 | EGA
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