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ProteomicsInteraction with ribosomal proteins accompanies ER stress-induction of the anticancer metallodrug BOLD-100/KP1339
The ruthenium-based anticancer agent BOLD-100/KP1339 has shown promising results in several in vitro and in vivo tumour models, as well as in early clinical trials. However, its mode of action remains to be fully elucidated. Recent evidence identified ER stress-induction and concomitant down-modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-06-01 | PXD022449 | Pride
Bold-100 Proteomics Kp1339 Target identification Anticancer agents 
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP1339-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080734 | MassIVE
UnknownInteraction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum.
Not available
S-EPMC7986094 | biostudies-literature
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP1339-treated HCT 116 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD004767 | Pride
Metallodrug Proteome profiling Mechanism of action Functional protein groups Response profiling 
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP1339-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo sapiens (Human) 
2017-01-11 | PXD004778 | Pride
Metallodrug Proteome profiling Mechanism of action Functional protein groups Response profiling 
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - nuclear proteins of KP1339-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD004793 | Pride
Metallodrug Proteome profiling Mechanism of action Functional protein groups Response profiling 
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - nuclear proteins of KP1339-treated HCT 116 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD004773 | Pride
Metallodrug Proteome profiling Mechanism of action Functional protein groups Response profiling 
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP1537-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080730 | MassIVE
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of untreated HCT 116 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080737 | MassIVE
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP772-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080736 | MassIVE
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