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ProteomicsCalreticulin mutated hematopoietic cells are vulnerable to ATR-CHK1 pathway inhibition
Disease frameshift mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF). To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we aimed to search for small molecule drugs th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD026803 | Pride
Mouse Mpn Calreticulin mutant Myeloproliferative neoplasms Atr-chk1 pathway 
TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
GenomicsChromosome 11 analysis in myeloid malignancies - WES
Blood samples from patients with myeloid malignancies were analyzed using whole exome sequencing (WES). Data set from genotyping by microarray of the same samples has been deposited in ArrayExpress under accession number E-MTAB-1845 (https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1845/).
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MTAB-1850 | biostudies-arrayexpress
TranscriptomicsGenetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predispose to myeloproliferative neoplasms
Genome-wide association study of JAK2 V617F negative myeloproliferative neoplasms consisting of 524 cases at stage 1
ORGANISM(S): Homo sapiens 
2015-02-20 | E-MTAB-3340 | biostudies-arrayexpress
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