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TranscriptomicsInterplay between c-Jun and TAp73M-NM-1/M-NM-2 contributes to the apoptosis-survival balance
The p53-family member p73 functions in various cellular signaling pathways and can have tumor suppressor properties. Several isoforms of p73 exist that differ considerably in their function. Whereas the functions of the N-terminal isoforms (TA and M-NM-^TNp73) and their opposing pro- and anti-apopto...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-15780 | biostudies-arrayexpress
GenomicsChIP-Seq sequencing of H3K9me2 in third instar Drosophila larvae
This study describes the epigenetic profiling of the H3K9me2 in wt Drosophila larvae, as well as in Drosophila larvae for which the euchromatic catalytic enzyme depositing H3K9me2 (EHMT) is knocked out. ChIP-Seq profiling of H3K9me2 in wt and EHMT KO third instar Drosophila larvae
ORGANISM(S): Drosophila melanogaster 
2011-01-05 | E-GEOD-22447 | biostudies-arrayexpress
ProteomicsContext-dependent regulatory mechanisms control site-specific information processing within the MEK/ERK module
The impact of the cellular context and receptor type on the dynamics of phosphorylation cycles in signaling pathways are unclear. We employ an unbiased approach to identify network alterations that explain phosphorylation dynamics of the MEK/ERK module in response to hepatocyte growth factor or inte...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080803 | MassIVE
TranscriptomicsTAp73 is a trophic factor essential for sperm cell adhesion and maturation in testis
A core evolutionary function of the p53 family is to protect the genomic integrity of gametes. However, the role of p73 in the male germline is unknown. Here we uncover that TAp73 unexpectedly functions as adhesion and maturation factor of the seminiferous epithelium orchestrating spermiogenesis. TA...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-46034 | biostudies-arrayexpress
TranscriptomicsTAp73 is essential for germ cell adhesion and maturation in testis
A core evolutionary function of the p53 family is to protect the genomic integrity of gametes. However, the role of p73 in the male germline is unknown. Here we uncover that TAp73 unexpectedly functions as adhesion and maturation factor of the seminiferous epithelium orchestrating spermiogenesis. TA...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-52124 | biostudies-arrayexpress
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