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TranscriptomicsTranscriptome profiling in 6-hydroxydopamine hemiparkinsonian rats reveals methamphetamine-mediated dopamine-independent changes in striatal gene expression.
Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle (MFB) is used extensively as a model of Parkinson’s disease. The present experiments examined whether a single injection of methamphetamine (METH) (2.5 mg/kg) could still influence striatal gene expression after 6-hydroxydop...
ORGANISM(S): Rattus norvegicus 
2010-09-21 | E-GEOD-24233 | biostudies-arrayexpress
GenomicsGenome-wide analysis of acetylated H4K5 binding offers new insights into the acute and chronic effects of METH on gene expression in the dorsal striatum
In contrast to the acute METH-induced transcriptional changes, chronic METH administration produces differential changes in IEG responses and blunts the striatal effects of a single METH injection (McCoy et al., 2011). These observations suggested that chromic METH might have caused changes in the m...
ORGANISM(S): Rattus norvegicus 
2013-02-28 | E-GEOD-42776 | biostudies-arrayexpress
TranscriptomicsEnhanced upregulation of CRH mRNA expression in the rat nucleus accumbens after a delayed second injection of methamphetamine
Methamphetamine (METH) is a widely abused illicit amphetamine that causes acute biochemical and molecular changes in the brain. However, there are very few studies that have investigated the long-term effects of a single METH exposure in adult animals. The purpose of this study was thus to determin...
ORGANISM(S): Rattus norvegicus 
2013-06-30 | E-GEOD-46717 | biostudies-arrayexpress
TranscriptomicsThe Sex-Specific Changes in Gene Expression and Behavior Induced by Chronic Toxoplasma Infection in Mice
The goal of this study was to identify the neural systems that underlie the behavorial changes in intermediate hosts of Toxoplasma gondii. Using a mouse whole genome microarray, we analyzed gene expression in the frontal cortex during the latent stages of infection. We found marked sex-dependent e...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-31207 | biostudies-arrayexpress
TranscriptomicspCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsal striatum
Neuroplastic changes in the dorsal striatum participate in the transition from casual drug use to habitual and compulsive drug taking. These alterations might also play a critical role in the development of methamphetamine (METH) addiction. Nevertheless, the molecular substrates that underlie habitu...
ORGANISM(S): Rattus norvegicus 
2012-05-31 | E-GEOD-38223 | biostudies-arrayexpress
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