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ProteomicsFrom LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver pathology worldwide, closely associated with obesity and metabolic disorders. Increasing evidence suggests that macrophages play a crucial role in the development of MASLD. Several human studies have shown an inver...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-01 | PXD056343 | Pride
Mouse Timstof pro 2 
ProteomicsDeletion of matrix metalloproteinase-12 improves energy metabolism and brown adipose tissue function in mice prone to develop cardiometabolic disease
Matrix metalloproteinase-12 (MMP12) is a proinflammatory protein secreted by macrophages. We have previously demonstrated that the genetic deletion of MMP12 in a cardiometabolic mouse model (low-density lipoprotein receptor-deficient (LdlrKO) mice fed a high-fat, sucrose- and cholesterol-enriched di...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-19 | PXD063623 | Pride
Cold exposure Untargeted proteomics Bat Mitochondrial processes Ldlr-deficient mice Mmp12 
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