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ProteomicsGenetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice
Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining the contributions of MMP12...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-05 | PXD046532 | Pride
Matrix metalloproteinase 12 Ldlr-deficient mice Cmd Mmp12 deficiency Proteomics 
GenomicsEffect of MMP12 inhibitor on gene expression
Effect of MMP12 inhibitor on gene expression
PRJNA606167 | ENA
TranscriptomicsExpression data from the lungs of Scnn1b-Transgenic and wild-type mice
Airway mucus obstruction triggers macrophage activation and MMP12-dependent emphysema microarray expression profiling of lungs from Scnn1b-Tg mice to search for emphysema candidate genes
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-49373 | biostudies-arrayexpress
GenomicsInsulin-stimulated glucose uptake in recombinant MMP12 treated 3T3-L1 cells
Insulin-stimulated glucose uptake in recombinant MMP12 treated 3T3-L1 cells
PRJNA840936 | ENA
GenomicsFibrogenic macrophages drive cardiac fibrosis via MMP12-mediated tissue remodeling
Fibrogenic macrophages drive cardiac fibrosis via MMP12-mediated tissue remodeling
PRJNA1238305 | ENA
TranscriptomicsEffect of MMP12 inhibitor on gene expression
Identifying changes in fat tissue gene expression in mice treated with or without mmp12 inhibitor. "Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages"
ORGANISM(S): Mus musculus 
2022-05-13 | GSE145133 | GEO
TranscriptomicsInsulin-stimulated glucose uptake in recombinant MMP12 treated 3T3-L1 cells
Microbiota contributes to induction of type 2 diabetes by high-fat/high-sugar (HFHS), but which organs/pathways are impacted by microbiota remains unknown. Using multi-organ network and transkingdom analyses, we found that microbiota-dependent. impairment of OXPHOS /mitochondria in white adipose tis...
ORGANISM(S): Mus musculus 
2022-05-27 | GSE203489 | GEO
GenomicsMMP12-dependent myofibroblast formation contributes to the nucleus pulposus fibrosis and intervertebral disc degeneration
MMP12-dependent myofibroblast formation contributes to the nucleus pulposus fibrosis and intervertebral disc degeneration
PRJNA1207573 | ENA
UnknownThe Emerging Role of MMP12 in the Oral Environment.
Not available
S-EPMC10002488 | biostudies-literature
ProteomicsDeletion of matrix metalloproteinase-12 improves energy metabolism and brown adipose tissue function in mice prone to develop cardiometabolic disease
Matrix metalloproteinase-12 (MMP12) is a proinflammatory protein secreted by macrophages. We have previously demonstrated that the genetic deletion of MMP12 in a cardiometabolic mouse model (low-density lipoprotein receptor-deficient (LdlrKO) mice fed a high-fat, sucrose- and cholesterol-enriched di...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-19 | PXD063623 | Pride
Cold exposure Untargeted proteomics Bat Mitochondrial processes Ldlr-deficient mice Mmp12 
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