Sort   by:  
 Page size 
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
MetabolomicsA profile of the joint Toxoplasma-host infection metabolome finds broad changes to metabolism and discovers a novel parasite metabolic capability
The obligate intracellular parasite Toxoplasma gondii is auxotrophic for several key metabolites and must scavenge these, and carbon sources like glucose. from the host. While the importance of metabolism to Toxoplasma infection it obvious, it is unclear how Toxoplasma infection actually changes met...
2019-05-10 | MTBLS899 | MetaboLights
TranscriptomicsTranscription profiling of hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia
Hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice were subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia.
ORGANISM(S): Mus musculus 
2005-12-31 | E-MEXP-496 | biostudies-arrayexpress
TranscriptomicsTranscriptional characterization of tomato roots response to iron deficiency
Iron (Fe) deficiency is a yield-limiting factor for a variety of field crops across the world and generally results from the interaction of limited soil Fe bioavailability and susceptible genotype cultivation. Tomato, a Strategy I, model plant for Fe deficiency, is an important economical crop. Toma...
ORGANISM(S): Solanum lycopersicum 
2012-03-22 | E-GEOD-31112 | biostudies-arrayexpress
ProteomicsSuccinylome-controlled antibiotic resistance in MRSA - Succinylome
A sucC and a sucD mutant from the Nebraska Transposon Mutant Library (NTML, Strain NE569 and NE1770) were found to be susceptible to cefoxitin and oxacillin when other mutations in TCA cycle genes did not affect their resistance to these antibiotics. The SucC strain (Strain NE569) accumulated Succin...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2021-03-02 | MSV000086971 | MassIVE
ProteomicsSuccinylome-controlled antibiotic resistance in MRSA - Global proteome
A sucC and a sucD mutant from the Nebraska Transposon Mutant Library (NTML, Strain NE569 and NE1770) were found to be susceptible to cefoxitin and oxacillin when other mutations in TCA cycle genes did not affect their resistance to these antibiotics. The SucC strain (Strain NE569) accumulated Succin...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2021-03-02 | MSV000086976 | MassIVE
TranscriptomicsThe Pseudomonas fluorescens Crc affects the length of the transition phase during diauxic growth
Pseudomonads, unlike enteric bacteria, prefer to utilize tricarboxylic acid cycle intermediates over glucose. The crc gene has been implicated to impart repression on glucose and other metabolic enzymes in various Pseudomonas species when grown in a mixture of glucose and various organic acids. The...
ORGANISM(S): Pseudomonas fluorescens 
2010-06-19 | E-GEOD-5829 | biostudies-arrayexpress
TranscriptomicsMetabolic imbalance caused by loss of malic enzymes in the legume endosymbiont Sinorhizobium meliloti
Malic enzymes decarboxylate the tricarboxylic acid (TCA) cycle intermediate malate to the glycolytic end-product pyruvate and are well positioned to regulate metabolic flux in central carbon metabolism. The bacterium Sinorhizobium meliloti has a NAD(P)-malic enzyme (DME) and a NADP-malic enzyme (TM...
ORGANISM(S): Sinorhizobium meliloti 
2015-07-25 | E-GEOD-71308 | biostudies-arrayexpress
UnknownSpatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience.
Not available
S-EPMC8294104 | biostudies-literature
MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
Sort   by:  
 Page size