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UnknownA machine-learning model for reducing misdiagnosis in heparin-induced thrombocytopenia: A prospective, multicenter, observational study.

Background

Diagnosing heparin-induced thrombocytopenia (HIT) at the bedside remains challenging, exposing a significant number of patients at risk of delayed diagnosis or overtreatment. We hypothesized that machine-learning algorithms could be utilized to develop a more accurate and user-fri...
S-EPMC9706528 | biostudies-literature
UnknownDeclining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination.

Background and purpose

High mortality rates have been reported in patients with cerebral venous sinus thrombosis (CVST) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) after vaccination with adenoviral vector SARS-CoV-2 vaccines. The aim of this study was to evaluate whether...
S-EPMC8652752 | biostudies-literature
GenomicsHost genotyping data from Dutch adult bacterial meningitis patients and linked bacterial genome sequences
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. This st...
EGAS00001005993 | EGA
Genomicsgenotyped_bacterial_meningitis
This study includes 1146 samples of host genotyping data (genotyped) from Illumina Omni arrays. Samples were collected from adults (>16 yrs) patients with CSF confirmed bacterial meningitis in the Netherlands between 2006 and 2015. Metadata includes patient outcome, species of bacteria, and for 4...
EGAD00010002328 | EGA
Genomicsimputed_bacterial_meningitis
This study includes 1146 samples of host genotyping data (imputed) from Illumina Omni arrays, using https://imputation.sanger.ac.uk/ with the Haplotype Reference Consortium v1.1. Samples were collected from adults (>16 yrs) patients with CSF confirmed bacterial meningitis in the Netherlands betwe...
EGAD00010002327 | EGA
GenomicsMeningene researchers data access committee
Data Access Committee EGAC00001002513
EGAC00001002513 | EGA
UnknownEffects of Cooking with Liquefied Petroleum Gas or Biomass on Stunting in Infants.

Background

Household air pollution is associated with stunted growth in infants. Whether the replacement of biomass fuel (e.g., wood, dung, or agricultural crop waste) with liquefied petroleum gas (LPG) for cooking can reduce the risk of stunting is unknown.

Methods

We conducted a ran...
S-EPMC12070489 | biostudies-literature
UnknownCurrent state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL.
Platform trials bring the promise of making clinical research more efficient and more patient centric. While their use has become more widespread, including their prominent role during the COVID-19 pandemic response, broader adoption of platform trials has been limited by the lack of experience and ...
S-EPMC10788209 | biostudies-literature
UnknownTransforming jet flavour tagging at ATLAS.
Jet flavour tagging enables the identification of jets originating from heavy-flavour quarks in proton-proton collisions at the Large Hadron Collider, playing a critical role in its physics programmes. This paper presents GN2, a transformer-based flavour tagging algorithm deployed by the ATLAS Colla...
S-EPMC12804921 | biostudies-literature
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