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TranscriptomicsTranscription profile of B cells isolated from peripheral lymph nodes of wild-type vs CCR7-/- mice
We investigated the transcriptional profile of B cells isolated from peripheral lymph nodes of CCR7-/-C57BL/6 and C57BL/6 mice respectively. B cells were sorted as follows: CD19+, CD3-, CD11c-, CD11b-, NK1.1-, GR-1-. Very few genes were differentially regulated in CCR7-/- B cells, however the expres...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-27885 | biostudies-arrayexpress
TranscriptomicsGenome-associated RNA Polymerase II includes the dissociable Rpb4/7 subcomplex
Yeast RNA polymerase (Pol) II consists of a ten-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immuno-precipitation coupled to h...
ORGANISM(S): Saccharomyces cerevisiae 
2008-07-29 | E-GEOD-12060 | biostudies-arrayexpress
TranscriptomicsIdentification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68
Murine gammaherpesvirus 68 (MHV-68) is closely related to Epstein-Barr virus (EBV) and KaposiM-bM-^@M-^Ys sarcoma-associated herpesvirus (KSHV) and provides a small animal model to study the pathogenesis of gammaherpesvirus (M-NM-3HV) infections. To completely explore the potential of the MHV-68 sys...
ORGANISM(S): Mus musculus 
2010-07-15 | E-GEOD-22938 | biostudies-arrayexpress
TranscriptomicsThe nucleosome remodeler SNF2L modulates WNT signaling for cellular homeostasis
ISWI is an evolutionary conserved ATPase that catalyzes nucleosome remodeling in several different complexes. Two mammalian ISWI orthologs, SNF2H and SNF2L, have specialized functions despite their high similarity. Due to the lack of reagents the functions of SN2L in human cells had not been establi...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-30471 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human colorectal carcinoma patients expressing either high or low levels of human guanylate binding protein-1 (GBP-1) to identify coregulated genes
The gene expression profile of 24 human colorectal carcinoma patients either expressing high (n=12) or low (n=12) levels of human guanylate binding protein-1 (GBP-1) were compared in order to identify coregulated genes.
ORGANISM(S): Homo sapiens 
2008-07-31 | E-MEXP-833 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of two novel primate-specific histone H3 variants H3.X and H3.Y
Nucleosomal incorporation of specialized histone variants is an important mechanism to generate different functional chromatin states. Here we report the identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. Their mRNAs are found in certain human cell ...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-22415 | biostudies-arrayexpress
TranscriptomicsEstrogen-dependent gene expression in human breast cancer cells relies upon proteosome-dependent monoubiquitination of histone H2B
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate e...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31118 | biostudies-arrayexpress
TranscriptomicsProteasome inhibition blocks estrogen-dependent gene transcription by decreasing histone H2B monoubiquitination in human breast cancer cells
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate est...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30931 | biostudies-arrayexpress
GenomicsThreonine-4 of Mammalian RNA Polymerase II CTD is Targeted by Polo-like Kinase-3 and Required for Transcriptional Elongation
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5M-bM-^@M-^Y and 3M-bM-^@M-^Y regi...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
TranscriptomicsEbf2-GFP in IEO cells
Comparison of Ebf2-expressing bone marrow mesenchymal cells from Ebf2-GFP heterozgous and Ebf2-GFP homozygous (=knock-out) mice
ORGANISM(S): Mus musculus 
2017-12-17 | E-MTAB-2254 | biostudies-arrayexpress
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