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TranscriptomicsTranscription profiling of human Burkitts lymphoma cell lines treated with trichostatin A vs controls
Histone acetylation alters the chromatin state and thus gene expression and cellular activities. In spite of various applications of Histone Deacetylase inhibitors (DACIs) their mechanism or selectivity is not fully understood. We studied the mechanism by which the DACI Trichostatin A upregulates th...
ORGANISM(S): Homo sapiens 
2006-08-07 | E-MEXP-403 | biostudies-arrayexpress
ProteomicsPromyelocytic leukemia protein (PML) is a regulator of eNSC differentiation, survival and mitochondrial metabolism.
OThis study identifies the tumor suppressor PML as a regulator of embryonic neural stem cell (eNSC) homeostasis, highlighting its role in their proliferation, differentiation and metabolism. Loss of the promyelocytic leukemia (PML) protein has been previously linked to abnormal proliferation and dif...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD059100 | Pride
Stem cell Ensc Pml 
ProteomicsPML regulates stem cell pluripotency through novel sumoy-lation targets: SUMO Proteomics
Abstract: The Promyelocytic Leukemia protein (PML) and its associated nuclear bodies have re-cently emerged as essential factors for maintaining the characteristics of embryonic stem (ES) cells. However, the full repertoire of PML driven gene regulatory events in ES cells is not resolved. In this re...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058024 | Pride
Promyelocytic leukemia protein (pml) Spalt homology 1 (sall1) Cell division cycle associated 8 (cdca8) Embryonic stem cells: es cells Proteomics Small ubiquitin-like modifier (sumo) 
TranscriptomicsTranscription profiling of mouse embryonic stem cell line CGR8 grown in presence of Leukemia Inhibitory Factor and treated with trichostatin A
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at the Institute for Molecular Biology and Biotechnology FORTH, Herakl...
ORGANISM(S): Mus musculus 
2009-07-10 | E-TABM-670 | biostudies-arrayexpress
TranscriptomicsMicroRNAs for fine-tuning of mouse Embryonic Stem Cell fate decision through regulation of TGF-β signaling
Over the past years, microRNAs (miRNAs) have emerged as crucial factors that regulate self-renewal and differentiation of embryonic stem cells (ESCs). Although much is known about their role in maintaining ESC pluripotency, the mechanisms by which they affect cell fate decisions remain poorly unders...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-76375 | biostudies-arrayexpress
ProteomicsPML regulates stem cell pluripotency through novel sumoy-lation targets: PML Proteomics
Abstract: The Promyelocytic Leukemia protein (PML) and its associated nuclear bodies have re-cently emerged as essential factors for maintaining the characteristics of embryonic stem (ES) cells. However, the full repertoire of PML driven gene regulatory events in ES cells is not resolved. In this re...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-23 | PXD057990 | Pride
Promyelocytic leukemia protein (pml) Spalt homology 1 (sall1) Cell division cycle associated 8 (cdca8) Embryonic stem cells: es cells Proteomics Small ubiquitin-like modifier (sumo) 
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