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TranscriptomicsChromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
A global view of PML-RAR? transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. Complete Abstract: The translocation t(15;17) generates the chimeric PML-RAR? transcription factor that is the initiating event of ...
ORGANISM(S): Homo sapiens 
2008-09-06 | E-GEOD-12641 | biostudies-arrayexpress
GenomicsPML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia
Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
TranscriptomicsEffect of PML/RARA on the transcriptome of preleukemic early promyelocytes vs PML/RARA-Flt3ITD leukemic promyelocytes
Transcriptional profiling of murine cells expressing PML/RARA at the early promyelocyte stage (4 weeks old, preleukemic) and in full blown PML/RARA leukemia generated by transducing PML/RARA bone marrow with a Flt3-ITD retroviral vector Two-conditions experiment: preleukemic early promyelocytes vs l...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-59431 | biostudies-arrayexpress
ProteomicsInvestigation of the arsenic regulated proteome of PML bodies
A proteomic analysis of PML bodies purified from U2OS cells expressing YFP-PMLV either treated or not with 1uM arsenic for 2 hours, in comparison with parallel purifications from wt-U2OS cells treated identically.
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD030330 | Pride
Pml-rara Arsenic Ubiquitin Sumo Pml P97 
TranscriptomicsThe induced APL cells generated by the transplantation of PML-RARA-transduced human CD34+ hematopoietic cells into immunodeficient mice
A humanized in vivo APL model has been established utilizing the retroviral transduction of PML-RARA into human CD34+ hematopoietic cells and the transplantation of these cells into immunodeficient mice. The resultant leukemia recapitulated human APL phenotypically, and was clustered in the same cat...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-49344 | biostudies-arrayexpress
GenomicsThe ability of PML/RARα to initiate leukemia is associated with markedly increased proliferation of promyelocytes despite minor changes in the transcriptome and epigenome.
Acute Promyelocytic Leukemia is characterized by the accumulation in the blood and bone marrow of promyelocytes. The PML/RARα fusion protein is identified as the primary abnormality implicated in the pathology, and is believed to prevent transcription of genes necessary for normal myeloid developmen...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-54038 | biostudies-arrayexpress
ProteomicsChanges to the PML body proteome in U2OS cells after 2h treatment with 1uM arsenic
To monitor changes in PML body compinents during exposure to 1uM arsenic for 2h in U2OS cells lacking endogenous PML but expressing YFP-PML (V).
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD041718 | Pride
Pml Arsenic U2os 
ProteomicsMonitoring post-translational modifications and associated proteomes of WT-PML-V and two mutants from acute promyelocytic leukaemia patients refractory for arsenic therapy: A216T-PML-V and L217F-PML-V
U2OS PML-/- cells were reconstituted with YFP-PML-V of three types: WT, A216T or L217F. These cell lines were used to purify YFP-PML bodies using anti-GFP nanobody beads from cells either treated or not with arsenic (1uM for 2h). Protein samples were monitored for PML post-translational modification...
ORGANISM(S): Homo sapiens (Human) 
2025-03-27 | PXD051743 | Pride
Pml arsenic sumo ubiquitin topors 
TranscriptomicsTranscription profiling of human normal bone marrow CD34+ cells, promyelocytes, and neutrophils and PR9 cell line PML-RARA induction time series
To better understand the pathogenesis of acute promyelocytic leukemia (APL, FAB M3 AML), we identified genes that are expressed differently in APL cells compared to other acute myeloid leukemia subtypes, and to normal promyelocytes. Comparative gene expression analysis of 14 M3, 62 other AML (M0, M1...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12662 | biostudies-arrayexpress
ProteomicsProximity labelling with TurboID shows that client proteins of PML NBs differ in three cell contexts
PML nuclear body (PML NB) recruits different client proteins under different cell context. We used TurboID proximity labeling (PL) method followed by MS to determine the composition of PML NBs in mESCs, differentiated cells, and NaAsO2-treated mESCs.
ORGANISM(S): Mus musculus (Mouse) 
2023-01-10 | PXD037432 | Pride
Pml Differentiation Mesc Turboid Naaso2 
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