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ProteomicsImpaired stability of tumor cells after targeting of lactate/pyruvate metabolism investigated by shotgun proteomics
Overexpression of heat shock proteins (HSPs), especially the major stress-inducible 72 kDa heat shock protein 70 (Hsp70), in malignant tumor cells is associated with therapeutic resistance. The heightened metabolic demand in tumor cells (Warburg effect) increases lactate dehydrogenase (LDH) activity...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026078 | Pride
Lc-msms Heat shock proteins Lactate/pyruvate metabolism Ldha/b double knockout Membrane hsp70 expression Radiosensitivity 
MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
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