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TranscriptomicsThe bromodomain protein BRD4 regulates splicing during heat shock
During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor developme...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-73471 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of matched colorectal normal, tumor and metastasis tissues and proof-of principal bioinformatics modeling of therapeutic consequences of miRNA applications
MiRNAs are discussed as diagnostic and therapeutic molecules. However, effective miRNA drug treatments with miRNAs are so far hampered by the complexity of the miRNA networks. To identify potential miRNA drugs in colorectal cancer, we profiled miRNA and mRNA expression in matching normal, tumor and ...
ORGANISM(S): Homo sapiens 
2013-09-18 | E-GEOD-46622 | biostudies-arrayexpress
GenomicsDAT_CancerMethodsPaper_SNVTumorFoci - samples
"Single nucleotide variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000035 | EGA
GenomicsDAT_CancerMethodsPaper_CNVTumorFoci - samples
"Copy number variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000036 | EGA
GenomicsDAT_CancerMethodsPaper_FFPE - samples
"SNV detection from formalin fixed paraffin embedded (FFPE) samples"
EGAD00001000033 | EGA
GenomicsDAT_CancerMethodsPaper_DNAAmounts - samples
"Usage of small amounts of DNA for Illumina sequencing"
EGAD00001000034 | EGA
Genomics"Targeted High Throughput Sequencing in Clinical Cancer Settings: Formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity"
"Background: Massively parallel sequencing technologies have brought an enormous increase in sequencing throughput. However, these technologies need to be further improved with regard to reproducibility and applicability to clinical samples and settings. Methods: Using identification of genetic var...
EGAS00001000136 | EGA
Genomics"Data Access Center Cancer Genomics Group"
Data Access Committee EGAC00001000030
EGAC00001000030 | EGA
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