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TranscriptomicsGeminin regulates the transcriptional and epigenetic status of neuronal fate promoting genes during mammalian neurogenesis
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ORGANISM(S): Xenopus laevis 
2012-12-06 | E-GEOD-39673 | biostudies-arrayexpress
TranscriptomicsAnalysis of conditional loss of Geminin in neural tube and paraxial tissues at E10.5 by laser capture microdissection
To better understand the role of Geminin during germ layer specification, we bred floxed Geminin mice to Mox2-Cre mice. Mutants (fl/fl; cre/o) had spinal neural tube defects with complete penetrance. We obtained neural tube and paraxial tissue by laser capture microdissection and analyzed total RNA...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-42052 | biostudies-arrayexpress
TranscriptomicsRegulation of neurogenin-dependent gene expression by geminin
Transcriptional targets of neurogenin (Ngnr1) were identified by over-expression of an inducible form of neurogenin in Xenopus ectodermal explants. The effects of co-expressing the nucleoprotein geminin on Ngnr1-dependent target gene transactivation were defined. Regulating the transition from line...
ORGANISM(S): Xenopus laevis 
2012-12-06 | E-GEOD-39658 | biostudies-arrayexpress
TranscriptomicsGeminin-regulated genes during neural fate acquisition of mouse embryonic stem cells
Formation of the complex vertebrate nervous system begins when pluripotent cells of the early embryo are directed to acquire a neural fate. Although cell intrinsic controls play an important role in this process, the molecular nature of this regulation is not well defined. Here we assessed the rol...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25737 | biostudies-arrayexpress
TranscriptomicsGeminin knockdown in embryonic stem cell-derived neural precursors
Regulating the transition from lineage-restricted progenitors to terminally differentiated cells is a central aspect of nervous system development. Here, we investigated the role of the nucleoprotein Geminin in regulating neurogenesis at a mechanistic level during both Xenopus primary neurogenesis a...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-39657 | biostudies-arrayexpress
TranscriptomicsGeminin represses mesendoderm cell fate acquisition in embryoid bodies
Geminin is a small nucleoprotein that neuralizes ectoderm in the Xenopus embryo. Geminin promotes neural fate acquisition of mouse embryonic stem cells: Geminin knockdown during neural fate acquisition decreased expression of neural precursor cell markers (Pax6, Sox1), while increasing expression of...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-39676 | biostudies-arrayexpress
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