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TranscriptomicsPersonalized medicine in psoriasis: developing a genomic classifier to predict histological response to Alefacept
Alefacept treatment is highly effective in a select group patients with moderate-to-severe psoriasis, and is an ideal candidate to develop systems to predict who will respond to therapy. A clinical trial of 22 patients with moderate to severe psoriasis treated with alefacept (7.5mg weekly i.v. x12 w...
ORGANISM(S): Homo sapiens 
2010-10-02 | E-GEOD-18948 | biostudies-arrayexpress
TranscriptomicsIntegrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
We sought to provide a comprehensive evaluation of the effects of TNF-α and IL-17 on the keratinocyte gene profile in order to identify genes that might be co-regulated by these cytokines. We then sought to determine how genes that were synergistically activated by both cytokines relate to the psori...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-24767 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of Psoriasis Using RNA-seq Reveals Previously Unidentified Differentially Expressed genes
The transcriptomic profiling of psoriasis has led to an increased understanding of disease pathogenesis. Although microarray technologies have been instrumental in this regard, it is clear that these tools detect an incomplete set of DEGs. RNA-seq can be used to supplement these prior technologies. ...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-41745 | biostudies-arrayexpress
TranscriptomicsTranscriptome of inflammatory myeloid DCs in psoriasis
Background: Previous work has identified CD11c+CD1c- dendritic cells (DCs) as the major 'inflammatory' dermal DC population in psoriasis vulgaris and CD1c+ DCs as the 'resident' cutaneous DC population. Objective: To further define molecular differences between these two myeloid dermal DC populatio...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20264 | biostudies-arrayexpress
TranscriptomicsCombined Use of Laser Capture Microdissection and Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions
In this study, we sought to establish the usefulness of LCM on cDNA microarray analysis. We reported that LCM samples improved the sensitivity of detection of differentially expressed genes over conventional bulk tissue analysis. We also provided the new information of chemokine and its receptor int...
ORGANISM(S): Homo sapiens 
2012-01-30 | E-GEOD-26866 | biostudies-arrayexpress
UnknownStandard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial.
Not available
S-EPMC4648090 | biostudies-literature
UnknownComprehensive multi-omic profiling of somatic mutations in malformations of cortical development.
Not available
S-EPMC9961399 | biostudies-literature
UnknownValidated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.
Not available
S-EPMC5159977 | biostudies-literature
UnknownBaseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial.
Not available
S-EPMC10336619 | biostudies-literature
UnknownMeasuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015.
Not available
S-EPMC5055583 | biostudies-literature
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