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UnknownGenome Sequences of Mycobacteriophages Amgine, Amohnition, Bella96, Cain, DarthP, Hammy, Krueger, LastHope, Peanam, PhelpsODU, Phrank, SirPhilip, Slimphazie, and Unicorn.
Not available
S-EPMC5721135 | biostudies-literature
TranscriptomicsTranscriptome of inflammatory myeloid DCs in psoriasis
Background: Previous work has identified CD11c+CD1c- dendritic cells (DCs) as the major 'inflammatory' dermal DC population in psoriasis vulgaris and CD1c+ DCs as the 'resident' cutaneous DC population. Objective: To further define molecular differences between these two myeloid dermal DC populatio...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20264 | biostudies-arrayexpress
TranscriptomicsIL-17A is an essential cytokine to sustain pathogenic cell activation and inflammatory gene circuits in psoriasis vulgaris
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies ...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-31652 | biostudies-arrayexpress
TranscriptomicsDominant Th1 and Minimal Th17 Skewing in Discoid Lupus Revealed by Transcriptomic Comparison with Psoriasis
Discoid lupus erythematosus (DLE) is the most common skin manifestation of lupus. Despite its high frequency in systemic lupus in addition to cases without extracutaneous manifestations, targeted treatments for DLE are lacking, likely because of a dearth of knowledge of the molecular landscape of DL...
ORGANISM(S): Homo sapiens 
2013-11-18 | E-GEOD-52471 | biostudies-arrayexpress
TranscriptomicsExpression data from skin biopsy samples from patients with moderate-to-severe psoriasis
A gene expression profiling sub-study was conducted in which skin biopsy samples were collected from 85 patients with moderate-to-severe psoriasis who were participating in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial. This analysis identified 4,175 probe-sets as being significantl...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-30999 | biostudies-arrayexpress
TranscriptomicsCombined Use of Laser Capture Microdissection and Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions
In this study, we sought to establish the usefulness of LCM on cDNA microarray analysis. We reported that LCM samples improved the sensitivity of detection of differentially expressed genes over conventional bulk tissue analysis. We also provided the new information of chemokine and its receptor int...
ORGANISM(S): Homo sapiens 
2012-01-30 | E-GEOD-26866 | biostudies-arrayexpress
TranscriptomicsBroad defects in epidermal cornification in atopic dermatitis (AD) identified through genomic analysis
In this study we used genomic profiling to characterize differences in expression of genes related to epidermal growth/differentiation and inflammatory circuits in skin lesions of psoriasis and atopic dermatitis (AD), comparing expression values to normal skin. Skin biopsies were collected from 9 pa...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-16161 | biostudies-arrayexpress
UnknownNeuronal α-Synuclein Disease Stage Progression over 5 Years.
Not available
S-EPMC12273616 | biostudies-literature
TranscriptomicsIL-17 induces an expanded range of downstream genes in reconstituted human epidermis model
Background: IL-17 is the defining cytokine of the Th17, Tc17, and γδ T cell populations that plays a critical role in mediating inflammation and autoimmunity. Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines with relevant contributions of IFN-γ, TNF-α, and IL-17....
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-52361 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human moncyte derived dendritic cells grown with/without Etanercept TNF inhibitor
The process for making monocyte derived DCs (moDCs) has been previously described (46). All analysis was performed on “day 5” immature DCs. Etanercept 10mg/mL was added to experimental wells on days 0, 2, and 4. We chose this concentration of etanercept as it approximates the plasma concentra...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9239 | biostudies-arrayexpress
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