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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
UnknownIdentification of positions in human aldolase a that are neutral for apparent K<sub>M</sub>.
Not available
S-EPMC11908651 | biostudies-literature
TranscriptomicsLong non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor positive primary breast cancer
Expression of HOX transcript antisense intergenic RNA (HOTAIR)—a long intergenic non-coding RNA (lincRNA)—has been examined in a variety of human cancers, and overexpression of HOTAIR is correlated with poor survival among breast, colon, and liver cancer patients. In this retrospective study, we exa...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-48408 | biostudies-arrayexpress
TranscriptomicsElucidating the RamA Regulon in Klebsiella pneumoniae
Directional RNAseq analyses was undertaken in Klebsiella pneumoniae Ecl8 and isogenic mutants Ecl8delta ramA and Ecl8delta ramR to determine the RamA regulon. All samples were grown in Luria Bertani broth until OD600 approx 0.6 prior to RNA extraction. Differential expression was determined using DE...
ORGANISM(S): Klebsiella pneumoniae 
2014-08-15 | E-ERAD-122 | biostudies-arrayexpress
TranscriptomicsLow input Hi-C datasets for a diffuse large B-cell lymphoma sample, healthy control human B-cells and mouse embryonic stem cells
In this experiment, we've examined chromatin conformation of OG2 (B6; CBA-Tg(Pou5f1-EGFP)2Mnn/J; stock number 004654) mouse stem cells cultured as described in (Shi et al., 2008), using different amounts of starting cells. We performed a modified in situ Hi-C protocol for 6 samples digested with Mbo...
ORGANISM(S): Mus musculus 
2018-11-30 | E-MTAB-5875 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Escherichia coli overexpressing dpiA vs wt
The dpiA and dpiB genes of Escherichia coli, which are orthologs of genes that regulate citrate uptake and utilization in Klebsiella pneumoniae, comprise a two-component signal transduction system that can modulate the replication of and destabilize the inheritance of pSC101 and certain other plasmi...
ORGANISM(S): Escherichia coli 
2005-12-06 | E-SMDB-3557 | biostudies-arrayexpress
TranscriptomicsDpiA overexpression
The dpiA and dpiB genes of Escherichia coli, which are orthologs of genes that regulate citrate uptake and utilization in Klebsiella pneumoniae, comprise a two-component signal transduction system that can modulate the replication of and destabilize the inheritance of pSC101 and certain other plasmi...
ORGANISM(S): Escherichia coli 
2006-01-30 | E-GEOD-4112 | biostudies-arrayexpress
ProteomicsCx37 Phosphorylation and cell cycle regulation
Using alanine and aspartate substitutions to mimic dephosphorylated and phosphorylated Cx37, respectively, we showed that induced expression of Cx37 in rat insulinoma cells could arrest cell cycle progression, support cell cycle progression or cause cell death in a phosphosite specific manner. In th...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-13 | PXD012191 | Pride
Gap junction  growth arrest  proliferation  cell death  differential phosphorylation 
ProteomicsSynergistic effects of polymyxin and vancomycin combinations on carbapenem- and polymyxin-resistant Klebsiella pneumoniae and their molecular characteristics
The emergence and spread of polymyxin resistance, especially among Klebsiella pneumoniae isolates threaten the effective management of infections. This study profiled for polymyxin resistance mechanisms and investigated the activity of polymyxins plus vancomycin against carbapenem- and polymyxin-res...
ORGANISM(S): Cellular Organisms 
2023-10-13 | PXD045685 | JPOST Repository
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