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MetabolomicsL-serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen

The emergence of high-virulent Acinetobacter baumannii strains increases the mortality of patients and seriously affects their prognosis, which motivates us to explore novel ways to control such infections. In this study, gas chromatography-mass spectrometry was adopted to explore the me...

2024-01-18 | MTBLS8966 | MetaboLights
ProteomicsProteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in Complement and coagulation cascades and Platelet activation pathways
Post-translational modifications (PTMs) are considered to be an important factor in the pathogenesis of SLE. Lysine 2-hydroxyisobutyryl (Khib), as an emerging post-translational modification of proteins, is involved in some important biological metabolic activities. We compared the Khib levels of SL...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040218 | Pride
Human Lysine 2-hydroxyisobutyryl Pbmc Sle 
UnknownProteomic and immunological identification of two new allergens from silkworm (Bombyx mori L.) pupae.
Not available
S-EPMC4472537 | biostudies-literature
UnknownLC-MS Metabolite Profiling and the Hypoglycemic Activity of Morus alba L. Extracts.
Not available
S-EPMC9457631 | biostudies-literature
UnknownCorrelating local structure and migration dynamics in Na/Li dual ion conductor Na5YSi4O12.
Not available
S-EPMC11331078 | biostudies-literature
UnknownNa+-NQR Confers Aminoglycoside Resistance via the Regulation of l-Alanine Metabolism.
Not available
S-EPMC7683393 | biostudies-literature
MetabolomicsTranscriptomic and metabolomic analysis of liver cirrhosis
Liver cirrhosis is one of the leading causes of decreased life expectancy worldwide. However, the molecular mechanisms underlying the development of liver cirrhosis remain unclear. In this study, we performed a comprehensive analysis using transcriptome and metabolome sequencing to explore the genes...
2024-08-07 | MTBLS5665 | MetaboLights
TranscriptomicsMurine Pancreatic Cancer Cells: KLF10 wild type vs KLF10 knockout
Transcriptional profiling of mouse pancreatic cancer cells comparing Pdx-1Cre LSL-KrasG12D P53L/L cells with Pdx-1Cre LSL-KrasG12D KLF10L/L P53L/L cells, and to determine the effects of KLF10 deficiency on murine PDAC gene expression. Two-condition experiment, Pdx-1Cre LSL-KrasG12D P53L/L cells vs. ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-85521 | biostudies-arrayexpress
UnknownPiezo1 Participated in Decreased L-Type Calcium Current Induced by High Hydrostatic Pressure via. CaM/Src/Pitx2 Activation in Atrial Myocytes.
Not available
S-EPMC8891577 | biostudies-literature
UnknownCathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.
Not available
S-EPMC6464228 | biostudies-literature
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