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UnknownA role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia.

Background

Pre-mRNAs of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propanoic acid (AMPA)/kainate glutamate receptors undergo post-transcriptional modification known as RNA editing that is mediated by adenosine deaminase acting on RNA type 2 (ADAR2). This modification alters the amino acid ...
S-EPMC3902024 | biostudies-literature
UnknownPhenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus.
Monoamine oxidase (MAO) is a key enzyme responsible for the degradation of neurotransmitters and trace amines. MAO has two subtypes (MAO-A and MAO-B) that are encoded by different genes. In the brain, MAO-B is highly expressed in the paraventricular thalamic nucleus (PVT); however, its substrate in ...
S-EPMC8742005 | biostudies-literature
UnknownUnbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability.

Background

The accumulation of mtDNA mutations in different tissues from various mouse models has been widely studied especially in the context of mtDNA mutation-driven ageing but has been confounded by the inherent limitations of the most widely used approaches. By implementing a method to ...
S-EPMC7585204 | biostudies-literature
UnknownDNA methylation and hydroxymethylation analyses of the active LINE-1 subfamilies in mice.
Retrotransposon long interspersed nuclear element-1 (LINE-1) occupies a large proportion of the mammalian genome, comprising approximately 100,000 genomic copies in mice. Epigenetic status of the 5' untranslated region (5'-UTR) of LINE-1 is critical for its promoter activity. DNA methylation levels ...
S-EPMC5648895 | biostudies-literature
UnknownCell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA.
Bipolar disorder (BD) is a severe psychiatric disorder characterized by repeated conflicting manic and depressive states. In addition to genetic factors, complex gene-environment interactions, which alter the epigenetic status in the brain, contribute to the etiology and pathophysiology of BD. Here,...
S-EPMC8740475 | biostudies-literature
UnknownHeterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.

Objective

Mutations in nuclear-encoded mitochondrial DNA (mtDNA) polymerase (POLG) are known to cause autosomal dominant chronic progressive external ophthalmoplegia (adCPEO) with accumulation of multiple mtDNA deletions in muscles. However, no animal model with a heterozygous Polg mutation ...
S-EPMC4265062 | biostudies-literature
UnknownDisturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis.
Bipolar disorder (BD) is a major global health burden, and its treatment challenges highlight the need for pathology-based therapeutic development. Emerging evidence suggests that the thalamus, particularly the paraventricular thalamic nucleus (PVT), is a key region in mood regulation. We performed ...
S-EPMC12873406 | biostudies-literature
UnknownAnt1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.
Although mitochondrial and serotonergic dysfunctions have been implicated in the etiology of bipolar disorder (BD), the relationship between these unrelated pathways has not been elucidated. A family of BD and chronic progressive external ophthalmoplegia (CPEO) caused by a mutation of the mitochondr...
S-EPMC6250678 | biostudies-literature
UnknownDepression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus.
Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitoc...
S-EPMC5414076 | biostudies-literature
UnknownSolid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma.

Introduction

Resistance to EGFR tyrosine kinase inhibitors is influenced by tumor-intrinsic and -extrinsic factors. We investigated the impact of tumor cell histology and tumor microenvironment on the efficacy of osimertinib.

Methods

We evaluated surgically resected adenocarcinoma fro...
S-EPMC11850751 | biostudies-literature
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