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TranscriptomicsThe Drosophila immune response towards entomopathogenic nematodes and their associated bacteria.
Entomopathogenic nematodes (EPNs) of the genera Heterorhabditis are obligate and lethal insect parasites. In recent years they have been used increasingly as biological control agents. These EPNs are symbiotically associated with bacteria of the genera Photorhabdus. The bacterial symbionts are essen...
ORGANISM(S): Drosophila melanogaster 
2014-03-07 | E-MTAB-1542 | biostudies-arrayexpress
TranscriptomicsComparison of transcription profile of Adenosine receptor (AdoR) null mutant and adenosine transporter (ENT2) partial mutant in Drosophila melanogaster 3rd instar larvae
Dysregulation of adenosine (Ado) homeostasis has been observed in both rodent models and human patients of Huntington’s disease (HD). However, the underlying mechanisms of Ado signaling in HD pathogenesis is still unclear. In this study we examined influence of Ado signaling on Drosophila HD model. ...
ORGANISM(S): Drosophila melanogaster 
2020-10-17 | E-MTAB-8699 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Adenosine receptor (AdoR) null mutant in Drosophila melanogaster imagoes
Dysregulation of adenosine (Ado) homeostasis has been observed in both rodent models and human patients of Huntington’s disease (HD). However, the underlying mechanisms of Ado signaling in HD pathogenesis is still unclear. In this study we examined influence of Ado signaling on Drosophila HD model. ...
ORGANISM(S): Drosophila melanogaster 
2020-10-17 | E-MTAB-8704 | biostudies-arrayexpress
TranscriptomicsA Drosophila chitinase-like protein has an immune function.
In the present study we analyzed the function of one member of Drosophila CLPs namely Drosophila IDGF3 with a special focus on immunity. We found that Idgf3 mutants are homozygous viable, and have defects in hemolymph clotting, which is the earliest of Drosophila larvae response after injury. We cou...
ORGANISM(S): Drosophila melanogaster 
2016-01-20 | E-MTAB-3478 | biostudies-arrayexpress
TranscriptomicsDrosophila Imaginal disc growth factor 2 promotes cell growth in vitro independently of insulin and is involved in innate immune response in vivo
Drosophila imaginal disc growth factors (IDGFs) comprise a small protein family of six members belonging to chitinase-like proteins (CLPs), which bind to, but do not cleave chitin or similar carbohydrates. IDGF2 is the prototypical member with known structure and reported to induce the proliferation...
ORGANISM(S): Drosophila melanogaster 
2016-06-27 | E-MTAB-5007 | biostudies-arrayexpress
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